論文 - 詳細
| RRC ID | 33635 |
|---|---|
| 著者 | Kubo F, Hablitzel B, Dal Maschio M, Driever W, Baier H, Arrenberg AB. |
| タイトル | Functional architecture of an optic flow-responsive area that drives horizontal eye movements in zebrafish. |
| ジャーナル | Neuron |
| Abstract |
Animals respond to whole-field visual motion with compensatory eye and body movements in order to stabilize both their gaze and position with respect to their surroundings. In zebrafish, rotational stimuli need to be distinguished from translational stimuli to drive the optokinetic and the optomotor responses, respectively. Here, we systematically characterize the neural circuits responsible for these operations using a combination of optogenetic manipulation and in vivo calcium imaging during optic flow stimulation. By recording the activity of thousands of neurons within the area pretectalis (APT), we find four bilateral pairs of clusters that process horizontal whole-field motion and functionally classify eleven prominent neuron types with highly selective response profiles. APT neurons are prevalently direction selective, either monocularly or binocularly driven, and hierarchically organized to distinguish between rotational and translational optic flow. Our data predict a wiring diagram of a neural circuit tailored to drive behavior that compensates for self-motion. |
| 巻・号 | 81(6) |
| ページ | 1344-1359 |
| 公開日 | 2014-3-19 |
| DOI | 10.1016/j.neuron.2014.02.043 |
| PII | S0896-6273(14)00193-7 |
| PMID | 24656253 |
| MeSH | Animals Eye Movements / physiology* Motion Perception / physiology Neurons / physiology* Nystagmus, Optokinetic / physiology Optic Flow / physiology* Photic Stimulation / methods Visual Fields / physiology Visual Pathways / physiology* Zebrafish / physiology* |
| IF | 14.415 |
| 引用数 | 74 |
| WOS 分野 | NEUROSCIENCES |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | News |
| 各媒体での言及数の合計 | 14 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ゼブラフィッシュ | Tg(slc17a6b:LOXP-DsRed-LOXP-GFP) isl1:GFP/rw0 |