論文 - 詳細
| RRC ID | 33666 |
|---|---|
| 著者 | Bosco A, Bureau C, Affaticati P, Gaspar P, Bally-Cuif L, Lillesaar C. |
| タイトル | Development of hypothalamic serotoninergic neurons requires Fgf signalling via the ETS-domain transcription factor Etv5b. |
| ジャーナル | Development |
| Abstract |
Serotonin is a monoamine neurotransmitter that is involved in numerous physiological functions and its dysregulation is implicated in various psychiatric diseases. In all non-placental vertebrates, serotoninergic (5-HT) neurons are present in several regions of the brain, including the hypothalamus. In placental mammals, however, 5-HT neurons are located in the raphe nuclei only. In all species, though, 5-HT neurons constitute a functionally and molecularly heterogeneous population. How the non-raphe 5-HT populations are developmentally encoded is unknown. Using the zebrafish model we show that, in contrast to the raphe populations, hypothalamic 5-HT neurons are generated independently of the ETS-domain transcription factor Pet1 (Fev). By applying a combination of pharmacological tools and gene knockdown and/or overexpression experiments, we demonstrate that Fgf signalling acts via another ETS-domain transcription factor, Etv5b (Erm), to induce hypothalamic 5-HT neurons. We provide evidence that Etv5b exerts its effects by regulating cell cycle parameters in 5-HT progenitors. Our results highlight a novel role for Etv5b in neuronal development and provide support for the existence of a developmental heterogeneity among 5-HT neurons in their requirement for ETS-domain transcription factors. |
| 巻・号 | 140(2) |
| ページ | 372-84 |
| 公開日 | 2013-1-15 |
| DOI | 10.1242/dev.089094 |
| PII | 140/2/372 |
| PMID | 23250211 |
| MeSH | Animals Biological Transport Cell Cycle Fibroblast Growth Factors / metabolism* Gene Expression Regulation, Developmental* Models, Biological Protein Structure, Tertiary Proto-Oncogene Proteins c-ets / metabolism* Raphe Nuclei / metabolism Serotonergic Neurons / metabolism* Serotonin / metabolism* Signal Transduction Stem Cells / cytology Transcription Factors / metabolism Zebrafish Zebrafish Proteins / metabolism |
| IF | 5.611 |
| 引用数 | 20 |
| WOS 分野 | DEVELOPMENTAL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ゼブラフィッシュ | Tg(EF1α:mKO2-zCdt1(1/190)/rw0405b Tg(EF1α:mAG-hGem(1/60)/rw0412a |