論文 - 詳細
| RRC ID | 33671 |
|---|---|
| 著者 | Kishimoto N, Asakawa K, Madelaine R, Blader P, Kawakami K, Sawamoto K. |
| タイトル | Interhemispheric asymmetry of olfactory input-dependent neuronal specification in the adult brain. |
| ジャーナル | Nat Neurosci |
| Abstract |
The vertebrate brain is anatomically and functionally asymmetric. The left and right cerebral hemispheres harbor neural stem cell niches at the ventricular-subventricular zone (V-SVZ) of the ventricular walls, where new neurons are continuously generated throughout life. However, any interhemispheric asymmetry of neural stem cell niches remains unclear. We performed gene-trap screens in adult zebrafish to identify genes that are differentially expressed in the two hemispheres and found that adult-born neurons expressing the neural zinc-finger protein Myt1 exist predominantly in the left V-SVZ. This lateralization could be reversed by left olfactory sensory deprivation-induced inactivation of Notch signaling. The olfactory behavioral preference for attractive amino acids was also impaired by sensory deprivation of the left olfactory system, but not of the right olfactory system. Our findings suggest that olfactory input generates interhemispheric differences in the fate of adult-born neurons in the zebrafish brain. |
| 巻・号 | 16(7) |
| ページ | 884-8 |
| 公開日 | 2013-7-1 |
| DOI | 10.1038/nn.3409 |
| PII | nn.3409 |
| PMID | 23685722 |
| MeSH | Age Factors Amino Acids / metabolism Amino Acids / pharmacology Animals Animals, Genetically Modified Catheter Ablation Cerebral Ventricles / metabolism Dipeptides / pharmacology Dose-Response Relationship, Drug Enzyme Inhibitors / pharmacology Epithelium / injuries Epithelium / physiology Functional Laterality / genetics Functional Laterality / physiology* Green Fluorescent Proteins / genetics Green Fluorescent Proteins / metabolism HSP70 Heat-Shock Proteins / metabolism Injections, Intraventricular Locomotion / drug effects Locomotion / physiology Nerve Tissue Proteins / metabolism Neurons / physiology* Odorants Olfactory Bulb / cytology* Olfactory Bulb / physiology Olfactory Pathways / cytology Olfactory Pathways / physiology* Zebrafish Zebrafish Proteins / genetics |
| IF | 20.071 |
| 引用数 | 8 |
| WOS 分野 | NEUROSCIENCES |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 7 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ゼブラフィッシュ | SAGFF(LF)31B, UAS:GFP |