論文 - 詳細
| RRC ID | 33691 |
|---|---|
| 著者 | Carlisle TC, Ribera AB. |
| タイトル | Connexin 35b expression in the spinal cord of Danio rerio embryos and larvae. |
| ジャーナル | J Comp Neurol |
| Abstract |
Electrical synapses are expressed prominently in the developing and mature nervous systems. Unlike chemical synapses, little is known about the developmental role of electrical synapses, reflecting the limitations imposed by the lack of selective pharmacological blockers. At a molecular level, the building blocks of electrical synapses are connexin proteins. In this study, we report the expression pattern for neuronally expressed connexin 35b (cx35b), the zebrafish orthologue of mammalian connexin (Cx) 36. We find that cx35b is expressed at the time of neural induction, indicating a possible early role in neural progenitor cells. Additionally, cx35b localizes to the ventral spinal cord during embryonic and early larval stages. We detect cx35b mRNA in secondary motor neurons (SMNs) and interneurons. We identified the premotor circumferential descending (CiD) interneuron as one interneuron subtype expressing cx35b. In addition, cx35b is present in other ventral interneurons of unknown subtype(s). This early expression of cx35b in SMNs and CiDs suggests a possible role in motor network function during embryonic and larval stages. |
| 巻・号 | 522(4) |
| ページ | 861-75 |
| 公開日 | 2014-3-1 |
| DOI | 10.1002/cne.23449 |
| PMID | 23939687 |
| PMC | PMC4059601 |
| MeSH | Age Factors Animals Animals, Genetically Modified Connexins / genetics Connexins / metabolism* Embryo, Nonmammalian Gene Expression Regulation, Developmental / genetics Gene Expression Regulation, Developmental / radiation effects* Larva Luminescent Proteins / genetics Luminescent Proteins / metabolism Neural Inhibition / physiology Neural Pathways / embryology Neural Pathways / growth & development Neural Pathways / metabolism Neurons / metabolism RNA, Messenger / metabolism Spinal Cord* / embryology Spinal Cord* / growth & development Spinal Cord* / metabolism Time Factors Zebrafish* / anatomy & histology Zebrafish* / embryology Zebrafish* / growth & development Zebrafish Proteins / genetics Zebrafish Proteins / metabolism |
| IF | 2.801 |
| 引用数 | 5 |
| WOS 分野 | ZOOLOGY NEUROSCIENCES |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ゼブラフィッシュ | Tg(isl1:GFP)/rw0 |