Reference - Detail
| RRC ID | 33717 |
|---|---|
| Author | Akagawa H, Hara Y, Togane Y, Iwabuchi K, Hiraoka T, Tsujimura H. |
| Title | The role of the effector caspases drICE and dcp-1 for cell death and corpse clearance in the developing optic lobe in Drosophila. |
| Journal | Dev Biol |
| Abstract |
In the developing Drosophila optic lobe, cell death occurs via apoptosis and in a distinctive spatio-temporal pattern of dying cell clusters. We analyzed the role of effector caspases drICE and dcp-1 in optic lobe cell death and subsequent corpse clearance using mutants. Neurons in many clusters required either drICE or dcp-1 and each one is sufficient. This suggests that drICE and dcp-1 function in cell death redundantly. However, dying neurons in a few clusters strictly required drICE but not dcp-1, but required drICE and dcp-1 when drICE activity was reduced via hypomorphic mutation. In addition, analysis of the mutants suggests an important role of effecter caspases in corpse clearance. In both null and hypomorphic drICE mutants, greater number of TUNEL-positive cells were observed than in wild type, and many TUNEL-positive cells remained until later stages. Lysotracker staining showed that there was a defect in corpse clearance in these mutants. All the results suggested that drICE plays an important role in activating corpse clearance in dying cells, and that an additional function of effector caspases is required for the activation of corpse clearance as well as that for carrying out cell death. |
| Volume | 404(2) |
| Pages | 61-75 |
| Published | 2015-8-15 |
| DOI | 10.1016/j.ydbio.2015.05.013 |
| PII | S0012-1606(15)00282-1 |
| PMID | 26022392 |
| MeSH | Animals Apoptosis / genetics* Caspases / genetics Caspases / metabolism* Drosophila / embryology* Drosophila Proteins / genetics Drosophila Proteins / metabolism* Eye / embryology Eye / innervation In Situ Nick-End Labeling Mutation / genetics Neurons / metabolism Optic Lobe, Nonmammalian / embryology* |
| IF | 2.896 |
| Times Cited | 6 |
| WOS Category | DEVELOPMENTAL BIOLOGY |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 3 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Drosophila | HMS00398 |