Reference - Detail
RRC ID | 3375 |
---|---|
Author | Bhalla N, Dernburg AF. |
Title | A conserved checkpoint monitors meiotic chromosome synapsis in Caenorhabditis elegans. |
Journal | Science |
Abstract |
We report the discovery of a checkpoint that monitors synapsis between homologous chromosomes to ensure accurate meiotic segregation. Oocytes containing unsynapsed chromosomes selectively undergo apoptosis even if a germline DNA damage checkpoint is inactivated. This culling mechanism is specifically activated by unsynapsed pairing centers, cis-acting chromosome sites that are also required to promote synapsis in Caenorhabditis elegans. Apoptosis due to synaptic failure also requires the C. elegans homolog of PCH2, a budding yeast pachytene checkpoint gene, which suggests that this surveillance mechanism is widely conserved. |
Volume | 310(5754) |
Pages | 1683-6 |
Published | 2005-12-9 |
DOI | 10.1126/science.1117468 |
PII | 310/5754/1683 |
PMID | 16339446 |
MeSH | Animals Apoptosis Caenorhabditis elegans / genetics Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / physiology Chromosome Pairing / physiology* Chromosome Segregation Disorders of Sex Development Female Genes, Helminth Male Meiosis* Mutation Oocytes / physiology Recombination, Genetic Transgenes X Chromosome / genetics X Chromosome / physiology |
IF | 41.846 |
Times Cited | 132 |
WOS Category | CELL BIOLOGY |
Resource | |
C.elegans | tm1458 |