Reference - Detail
| RRC ID | 3376 |
|---|---|
| Author | Branicky R, Hekimi S. |
| Title | Specification of muscle neurotransmitter sensitivity by a Paired-like homeodomain protein in Caenorhabditis elegans. |
| Journal | Development |
| Abstract |
The effects of neurotransmitters depend on the receptors expressed on the target cells. In Caenorhabditis elegans, there are two types of GABA receptors that elicit opposite effects: excitatory receptors that open cation-selective channels, and inhibitory receptors that open anion-selective channels. The four non-striated enteric muscle cells required for the expulsion step of the defecation behavior are all sensitive to GABA: the sphincter muscle expresses a classical GABA-sensitive chloride channel (UNC-49) and probably relaxes in response to GABA, while the other three cells express a cation-selective channel (EXP-1) and contract. Here we show that the expression of the exp-1 gene is under the control of dsc-1, which encodes a Paired-like homeodomain protein, a class of transcription factors previously associated with the terminal differentiation of neurons in C. elegans. dsc-1 mutants have anatomically normal enteric muscles but are expulsion defective. We show that this defect is due to the lack of expression of exp-1 in the three cells that contract in response to GABA. In addition, dsc-1, but not exp-1, affects the periodicity of the behavior, revealing an unanticipated role for the enteric muscles in regulating this ultradian rhythm. |
| Volume | 132(22) |
| Pages | 4999-5009 |
| Published | 2005-11-1 |
| DOI | 10.1242/dev.02069 |
| PII | dev.02069 |
| PMID | 16236771 |
| MeSH | Amino Acid Sequence Animals Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / biosynthesis Caenorhabditis elegans Proteins / genetics* Caenorhabditis elegans Proteins / physiology Defecation / genetics Defecation / physiology Helminth Proteins / biosynthesis Helminth Proteins / genetics Helminth Proteins / physiology* Homeodomain Proteins / biosynthesis Homeodomain Proteins / genetics Homeodomain Proteins / physiology* Intestinal Mucosa / metabolism* Molecular Sequence Data Muscle Proteins / biosynthesis Muscle Proteins / genetics Muscle Proteins / physiology* Neurotransmitter Agents / pharmacology* Receptors, GABA / biosynthesis Receptors, GABA / genetics Sequence Deletion |
| IF | 5.611 |
| Times Cited | 7 |
| WOS Category | DEVELOPMENTAL BIOLOGY |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 1 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| C.elegans | tm241 |