論文 - 詳細
RRC ID | 3391 |
---|---|
著者 | Nakamura K, Kim S, Ishidate T, Bei Y, Pang K, Shirayama M, Trzepacz C, Brownell DR, Mello CC. |
タイトル | Wnt signaling drives WRM-1/beta-catenin asymmetries in early C. elegans embryos. |
ジャーナル | Genes Dev |
Abstract |
beta-Catenin regulates cell adhesion and cellular differentiation during development, and misregulation of beta-catenin contributes to numerous forms of cancer in humans. Here we describe Caenorhabditis elegans conditional alleles of mom-2/Wnt, mom-4/Tak1, and wrm-1/beta-catenin. We use these reagents to examine the regulation of WRM-1/beta-catenin during a Wnt-signaling-induced asymmetric cell division. While WRM-1 protein initially accumulates in the nuclei of all cells, signaling promotes the retention of WRM-1 in nuclei of responding cells. We show that both PRY-1/Axin and the nuclear exportin homolog IMB-4/CRM-1 antagonize signaling. These findings reveal how Wnt signals direct the asymmetric localization of beta-catenin during polarized cell division. |
巻・号 | 19(15) |
ページ | 1749-54 |
公開日 | 2005-8-1 |
DOI | 10.1101/gad.1323705 |
PII | 19/15/1749 |
PMID | 16077004 |
PMC | PMC1182335 |
MeSH | Amino Acid Sequence Animals Caenorhabditis elegans / embryology* Caenorhabditis elegans / metabolism Caenorhabditis elegans Proteins / chemistry Caenorhabditis elegans Proteins / metabolism* Cell Division Cell Nucleus / metabolism Cell Polarity Cytoskeletal Proteins / metabolism* Green Fluorescent Proteins / metabolism Intercellular Signaling Peptides and Proteins / metabolism* Membrane Proteins / chemistry Membrane Proteins / metabolism Molecular Sequence Data Sequence Homology, Amino Acid Signal Transduction* Trans-Activators / metabolism* Wnt Proteins beta Catenin |
IF | 9.527 |
引用数 | 66 |
WOS 分野 | GENETICS & HEREDITY DEVELOPMENTAL BIOLOGY CELL BIOLOGY |
リソース情報 | |
線虫 | tm514 |