Reference - Detail
|Author||Arata Y, Kouike H, Zhang Y, Herman MA, Okano H, Sawa H.|
|Title||Wnt signaling and a Hox protein cooperatively regulate psa-3/Meis to determine daughter cell fate after asymmetric cell division in C. elegans.|
Asymmetric cell division is a mechanism for achieving cellular diversity. In C. elegans, many asymmetric cell divisions are controlled by the Wnt-MAPK pathway through POP-1/TCF. It is poorly understood, however, how POP-1 determines the specific fates of daughter cells. We found that nob-1/Hox, ceh-20/Pbx, and a Meis-related gene, psa-3, are required for asymmetric division of the T hypodermal cell. psa-3 expression was asymmetric between the T cell daughters, and it was regulated by POP-1 through a POP-1 binding site in the psa-3 gene. psa-3 expression was also regulated by NOB-1 and CEH-20 through a NOB-1 binding sequence in a psa-3 intron. PSA-3 can bind CEH-20 and function after the T cell division to promote the proper fate of the daughter cell. These results indicate that cooperation between Wnt signaling and a Hox protein functions to determine the specific fate of a daughter cell.
|MeSH||Active Transport, Cell Nucleus Amino Acid Sequence Animals Animals, Genetically Modified Binding Sites / genetics Caenorhabditis elegans / cytology* Caenorhabditis elegans / genetics Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism Caenorhabditis elegans Proteins / physiology* Cell Division Genes, Helminth Green Fluorescent Proteins / genetics Green Fluorescent Proteins / metabolism Homeodomain Proteins / genetics Homeodomain Proteins / metabolism Homeodomain Proteins / physiology* Introns Molecular Sequence Data Sequence Homology, Amino Acid Signal Transduction Transcription Factors / genetics Transcription Factors / metabolism Wnt Proteins / genetics Wnt Proteins / physiology*|
|WOS Category||DEVELOPMENTAL BIOLOGY CELL BIOLOGY|