論文 - 詳細
| RRC ID | 3406 |
|---|---|
| 著者 | Arata Y, Kouike H, Zhang Y, Herman MA, Okano H, Sawa H. |
| タイトル | Wnt signaling and a Hox protein cooperatively regulate psa-3/Meis to determine daughter cell fate after asymmetric cell division in C. elegans. |
| ジャーナル | Dev Cell |
| Abstract |
Asymmetric cell division is a mechanism for achieving cellular diversity. In C. elegans, many asymmetric cell divisions are controlled by the Wnt-MAPK pathway through POP-1/TCF. It is poorly understood, however, how POP-1 determines the specific fates of daughter cells. We found that nob-1/Hox, ceh-20/Pbx, and a Meis-related gene, psa-3, are required for asymmetric division of the T hypodermal cell. psa-3 expression was asymmetric between the T cell daughters, and it was regulated by POP-1 through a POP-1 binding site in the psa-3 gene. psa-3 expression was also regulated by NOB-1 and CEH-20 through a NOB-1 binding sequence in a psa-3 intron. PSA-3 can bind CEH-20 and function after the T cell division to promote the proper fate of the daughter cell. These results indicate that cooperation between Wnt signaling and a Hox protein functions to determine the specific fate of a daughter cell. |
| 巻・号 | 11(1) |
| ページ | 105-15 |
| 公開日 | 2006-7-1 |
| DOI | 10.1016/j.devcel.2006.04.020 |
| PII | S1534-5807(06)00253-X |
| PMID | 16824957 |
| MeSH | Active Transport, Cell Nucleus Amino Acid Sequence Animals Animals, Genetically Modified Binding Sites / genetics Caenorhabditis elegans / cytology* Caenorhabditis elegans / genetics Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism Caenorhabditis elegans Proteins / physiology* Cell Division Genes, Helminth Green Fluorescent Proteins / genetics Green Fluorescent Proteins / metabolism Homeodomain Proteins / genetics Homeodomain Proteins / metabolism Homeodomain Proteins / physiology* Introns Molecular Sequence Data Sequence Homology, Amino Acid Signal Transduction Transcription Factors / genetics Transcription Factors / metabolism Wnt Proteins / genetics Wnt Proteins / physiology* |
| IF | 10.092 |
| 引用数 | 46 |
| WOS 分野 | DEVELOPMENTAL BIOLOGY CELL BIOLOGY |
| リソース情報 | |
| 線虫 | tm656 tm657 |