論文 - 詳細
| RRC ID | 3424 |
|---|---|
| 著者 | Foehr ML, Lindy AS, Fairbank RC, Amin NM, Xu M, Yanowitz J, Fire AZ, Liu J. |
| タイトル | An antagonistic role for the C. elegans Schnurri homolog SMA-9 in modulating TGFbeta signaling during mesodermal patterning. |
| ジャーナル | Development |
| Abstract |
In C. elegans, the Sma/Mab TGFbeta signaling pathway regulates body size and male tail patterning. SMA-9, the C. elegans homolog of Schnurri, has been shown to function as a downstream component to mediate the Sma/Mab TGFbeta signaling pathway in these processes. We have discovered a new role for SMA-9 in dorsoventral patterning of the C. elegans post-embryonic mesoderm, the M lineage. In addition to a small body size, sma-9 mutant animals exhibit a dorsal-to-ventral fate transformation within the M lineage. This M lineage defect of sma-9 mutants is unique in that animals carrying mutations in all other known components of the TGFbeta pathway exhibit no M lineage defects. Surprisingly, mutations in the core components of the Sma/Mab TGFbeta signaling pathway suppressed the M lineage defects of sma-9 mutants without suppressing their body size defects. We show that this suppression specifically happens within the M lineage. Our studies have uncovered an unexpected role of SMA-9 in antagonizing the TGFbeta signaling pathway during mesodermal patterning, suggesting a novel mode of function for the SMA-9/Schnurri family of proteins. |
| 巻・号 | 133(15) |
| ページ | 2887-96 |
| 公開日 | 2006-8-1 |
| DOI | 10.1242/dev.02476 |
| PII | dev.02476 |
| PMID | 16790477 |
| MeSH | Animals Animals, Genetically Modified Body Patterning Body Size Caenorhabditis elegans / embryology* Caenorhabditis elegans / genetics Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / physiology* Embryo, Nonmammalian / physiology* Gene Deletion Mesoderm / physiology* Signal Transduction Transcription Factors / deficiency Transcription Factors / genetics Transcription Factors / physiology* Transforming Growth Factor beta / antagonists & inhibitors* Zinc Fingers |
| IF | 5.611 |
| 引用数 | 28 |
| WOS 分野 | DEVELOPMENTAL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| 線虫 | tm572 |