論文 - 詳細
| RRC ID | 34543 |
|---|---|
| 著者 | Nishimura T, Sato T, Yamamoto Y, Watakabe I, Ohkawa Y, Suyama M, Kobayashi S, Tanaka M. |
| タイトル | Sex determination. foxl3 is a germ cell-intrinsic factor involved in sperm-egg fate decision in medaka. |
| ジャーナル | Science |
| Abstract |
Sex determination is an essential step in the commitment of a germ cell to a sperm or egg. However, the intrinsic factors that determine the sexual fate of vertebrate germ cells are unknown. Here, we show that foxl3, which is expressed in germ cells but not somatic cells in the gonad, is involved in sperm-egg fate decision in medaka fish. Adult XX medaka with disrupted foxl3 developed functional sperm in the expanded germinal epithelium of a histologically functional ovary. In chimeric medaka, mutant germ cells initiated spermatogenesis in female wild-type gonad. These results indicate that a germ cell-intrinsic cue for the sperm-egg fate decision is present in medaka and that spermatogenesis can proceed in a female gonadal environment. |
| 巻・号 | 349(6245) |
| ページ | 328-31 |
| 公開日 | 2015-7-17 |
| DOI | 10.1126/science.aaa2657 |
| PII | science.aaa2657 |
| PMID | 26067255 |
| MeSH | Animals Female Forkhead Transcription Factors / genetics Forkhead Transcription Factors / physiology* Male Oocytes / cytology Oocytes / physiology* Oryzias / genetics Oryzias / growth & development* Sex Determination Processes / genetics* Spermatogenesis / genetics Spermatozoa / cytology Spermatozoa / physiology* |
| IF | 41.846 |
| 引用数 | 52 |
| WOS 分野 | DEVELOPMENTAL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 81 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| メダカ | cDNAs BAC and fosmids clones |