Reference - Detail
| RRC ID | 35114 |
|---|---|
| Author | Stark A, Bushati N, Jan CH, Kheradpour P, Hodges E, Brennecke J, Bartel DP, Cohen SM, Kellis M. |
| Title | A single Hox locus in Drosophila produces functional microRNAs from opposite DNA strands. |
| Journal | Genes Dev |
| Abstract |
MicroRNAs (miRNAs) are approximately 22-nucleotide RNAs that are processed from characteristic precursor hairpins and pair to sites in messages of protein-coding genes to direct post-transcriptional repression. Here, we report that the miRNA iab-4 locus in the Drosophila Hox cluster is transcribed convergently from both DNA strands, giving rise to two distinct functional miRNAs. Both sense and antisense miRNA products target neighboring Hox genes via highly conserved sites, leading to homeotic transformations when ectopically expressed. We also report sense/antisense miRNAs in mouse and find antisense transcripts close to many miRNAs in both flies and mammals, suggesting that additional sense/antisense pairs exist. |
| Volume | 22(1) |
| Pages | 8-13 |
| Published | 2008-1-1 |
| DOI | 10.1101/gad.1613108 |
| PII | 22/1/8 |
| PMID | 18172160 |
| PMC | PMC2151017 |
| MeSH | Animals Base Sequence Body Patterning DNA / chemistry Drosophila / genetics* Drosophila / growth & development Drosophila / metabolism Gene Expression Regulation, Developmental Genes, Homeobox* Genes, Insect Genome Humans Mice MicroRNAs / biosynthesis* MicroRNAs / genetics Models, Genetic Molecular Sequence Data Nucleic Acid Conformation RNA, Antisense / metabolism |
| IF | 9.527 |
| Times Cited | 174 |
| WOS Category | DEVELOPMENTAL BIOLOGY GENETICS & HEREDITY CELL BIOLOGY |
| Altmetric score |
オルトメトリクス指標項目
|
| The most frequently cited source | Wikipedia |
| Total number of mentions | 3 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Drosophila | |