RRC ID 35184
著者 Nose A, Takeichi M, Goodman CS.
タイトル Ectopic expression of connectin reveals a repulsive function during growth cone guidance and synapse formation.
ジャーナル Neuron
Abstract Connectin, a cell surface protein of the leucine-rich repeat family in Drosophila, is expressed on the surface of a subset of embryonic muscles (primarily lateral muscles), on the growth cones and axons of the motoneurons that innervate these muscles (primarily SNa motoneurons), and on several associated glial cells. When coupled with its ability to mediate homophilic cell adhesion, these results led to the suggestion that Connectin functions as an attractive signal for SNa pathfinding and targeting. In the present study, we ectopically expressed Connectin on ventral muscles normally innervated by SNb motoneurons. The SNb growth cones change both their morphology and their trajectory when they encounter ectopic Connectin-positive ventral muscles, displaying "bypass," "detour," and "stall" phenotypes. Moreover, SNb synapse formation is prevented by Connectin expression on ventral muscles. These results reveal a repulsive function for Connectin during motoneuron growth cone guidance and synapse formation.
巻・号 13(3)
ページ 525-39
公開日 1994-9-1
DOI 10.1016/0896-6273(94)90023-x
PII 0896-6273(94)90023-X
PMID 7917289
MeSH Animals Axons / physiology* Connectin Drosophila Genes, Insect Larva Muscle Proteins / genetics Muscle Proteins / metabolism* Muscle Proteins / physiology* Mutation Protein Kinases* Reference Values Synapses / physiology* Synaptic Transmission Tissue Distribution
IF 14.415
引用数 123
WOS 分野 NEUROSCIENCES
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