論文 - 詳細
| RRC ID | 35190 |
|---|---|
| 著者 | Qin Y, Polacek N, Vesper O, Staub E, Einfeldt E, Wilson DN, Nierhaus KH. |
| タイトル | The highly conserved LepA is a ribosomal elongation factor that back-translocates the ribosome. |
| ジャーナル | Cell |
| Abstract |
The ribosomal elongation cycle describes a series of reactions prolonging the nascent polypeptide chain by one amino acid and driven by two universal elongation factors termed EF-Tu and EF-G in bacteria. Here we demonstrate that the extremely conserved LepA protein, present in all bacteria and mitochondria, is a third elongation factor required for accurate and efficient protein synthesis. LepA has the unique function of back-translocating posttranslocational ribosomes, and the results suggest that it recognizes ribosomes after a defective translocation reaction and induces a back-translocation, thus giving EF-G a second chance to translocate the tRNAs correctly. We suggest renaming LepA as elongation factor 4 (EF4). |
| 巻・号 | 127(4) |
| ページ | 721-33 |
| 公開日 | 2006-11-17 |
| DOI | 10.1016/j.cell.2006.09.037 |
| PII | S0092-8674(06)01298-0 |
| PMID | 17110332 |
| MeSH | Amino Acid Sequence Computational Biology Conserved Sequence* Escherichia coli / metabolism* Escherichia coli Proteins / chemistry Escherichia coli Proteins / metabolism* GTP Phosphohydrolases / metabolism Green Fluorescent Proteins / metabolism Models, Genetic Molecular Sequence Data Peptide Elongation Factor G / chemistry Peptide Elongation Factors / metabolism* Peptide Initiation Factors Phylogeny Protein Biosynthesis / genetics* Protein Structure, Secondary Protein Structure, Tertiary Ribosomes / metabolism* Transcription, Genetic Transcriptional Elongation Factors / chemistry Transcriptional Elongation Factors / metabolism* |
| IF | 38.637 |
| 引用数 | 150 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 8 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 原核生物(大腸菌) | |