RRC ID 352
Author Hirota Y, Sawamoto K, Takahashi K, Ueda R, Okano H.
Title The transmembrane protein, Tincar, is involved in the development of the compound eye in Drosophila melanogaster.
Journal Dev. Genes Evol.
Abstract We previously cloned and characterized the Drosophila gene, tincar (tinc), which encodes a novel protein with eight putative transmembrane domains. Here, we have studied the expression pattern and functions of tinc during developmental processes. tinc mRNA is expressed in the central and peripheral nervous systems, and midgut during embryogenesis. In the third-instar larval eye disc, tinc mRNA is strongly expressed in all the differentiating ommatidial cells within and in the vicinity of the morphogenetic furrow. Loss-of-function analysis using the RNA-interference method revealed severe defects of eye morphogenesis during the late developmental stages. Our results suggested that tinc may have an indispensable role in the normal differentiation of ommatidial cells.
Volume 215(2)
Pages 90-6
Published 2005-2
DOI 10.1007/s00427-004-0452-y
PMID 15654626
MeSH Animals Cell Differentiation Drosophila Proteins / genetics Drosophila Proteins / physiology* Drosophila melanogaster / embryology* Drosophila melanogaster / genetics Drosophila melanogaster / growth & development Eye / cytology Eye / embryology* Eye / growth & development Membrane Proteins / genetics Membrane Proteins / physiology* RNA Interference RNA, Messenger / analysis RNA, Messenger / metabolism
IF 2.125
Times Cited 1
WOS Category EVOLUTIONARY BIOLOGY CELL BIOLOGY DEVELOPMENTAL BIOLOGY
Resource
Drosophila 7723R-1 7723R-3