論文 - 詳細
| RRC ID | 3522 |
|---|---|
| 著者 | Meier B, Clejan I, Liu Y, Lowden M, Gartner A, Hodgkin J, Ahmed S. |
| タイトル | trt-1 is the Caenorhabditis elegans catalytic subunit of telomerase. |
| ジャーナル | PLoS Genet |
| Abstract |
Mutants of trt-1, the Caenorhabditis elegans telomerase reverse transcriptase, reproduce normally for several generations but eventually become sterile as a consequence of telomere erosion and end-to-end chromosome fusions. Telomere erosion and uncapping do not cause an increase in apoptosis in the germlines of trt-1 mutants. Instead, late-generation trt-1 mutants display chromosome segregation defects that are likely to be the direct cause of sterility. trt-1 functions in the same telomere replication pathway as mrt-2, a component of the Rad9/Rad1/Hus1 (9-1-1) proliferating cell nuclear antigen-like sliding clamp. Thus, the 9-1-1 complex may be required for telomerase to act at chromosome ends in C. elegans. Although telomere erosion limits replicative life span in human somatic cells, neither trt-1 nor telomere shortening affects postmitotic aging in C. elegans. These findings illustrate effects of telomere dysfunction in C. elegans mutants lacking the catalytic subunit of telomerase, trt-1. |
| 巻・号 | 2(2) |
| ページ | e18 |
| 公開日 | 2006-2-1 |
| DOI | 10.1371/journal.pgen.0020018 |
| PMID | 16477310 |
| PMC | PMC1361356 |
| MeSH | Animals Apoptosis Caenorhabditis elegans Caenorhabditis elegans Proteins / physiology Catalysis Catalytic Domain DNA Replication DNA-Binding Proteins / genetics* Genes, Helminth Germ-Line Mutation Mitosis Mutation* Telomerase / genetics* Telomere / ultrastructure* |
| IF | 5.175 |
| 引用数 | 61 |
| WOS 分野 | GENETICS & HEREDITY |
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オルトメトリクス指標項目
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| 最多言及媒体 | Wikipedia |
| 各媒体での言及数の合計 | 4 |
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| 線虫 | tm899 |