RRC ID 3522
Author Meier B, Clejan I, Liu Y, Lowden M, Gartner A, Hodgkin J, Ahmed S.
Title trt-1 is the Caenorhabditis elegans catalytic subunit of telomerase.
Journal PLoS Genet.
Abstract Mutants of trt-1, the Caenorhabditis elegans telomerase reverse transcriptase, reproduce normally for several generations but eventually become sterile as a consequence of telomere erosion and end-to-end chromosome fusions. Telomere erosion and uncapping do not cause an increase in apoptosis in the germlines of trt-1 mutants. Instead, late-generation trt-1 mutants display chromosome segregation defects that are likely to be the direct cause of sterility. trt-1 functions in the same telomere replication pathway as mrt-2, a component of the Rad9/Rad1/Hus1 (9-1-1) proliferating cell nuclear antigen-like sliding clamp. Thus, the 9-1-1 complex may be required for telomerase to act at chromosome ends in C. elegans. Although telomere erosion limits replicative life span in human somatic cells, neither trt-1 nor telomere shortening affects postmitotic aging in C. elegans. These findings illustrate effects of telomere dysfunction in C. elegans mutants lacking the catalytic subunit of telomerase, trt-1.
Volume 2(2)
Pages e18
Published 2006-2
DOI 10.1371/journal.pgen.0020018
PMID 16477310
PMC PMC1361356
MeSH Animals Apoptosis Caenorhabditis elegans Caenorhabditis elegans Proteins / physiology Catalysis Catalytic Domain DNA Replication DNA-Binding Proteins / genetics* Genes, Helminth Germ-Line Mutation Mitosis Mutation* Telomerase / genetics* Telomere / ultrastructure*
IF 5.224
Times Cited 46
WOS Category GENETICS & HEREDITY
Resource
C.elegans tm899