論文 - 詳細
RRC ID | 353 |
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著者 | Kanai MI, Okabe M, Hiromi Y. |
タイトル | seven-up Controls switching of transcription factors that specify temporal identities of Drosophila neuroblasts. |
ジャーナル | Dev Cell |
Abstract |
Drosophila neuronal stem cell neuroblasts (NB) constantly change character upon division, to produce a different type of progeny at the next division. Transcription factors Hunchback (HB), Krüppel (KR), Pdm (PDM), etc. are expressed sequentially in each NB and act as determinants of birth-order identity. How a NB switches its expression profile from one transcription factor to the next is poorly understood. We show that the HB-to-KR switch is directed by the nuclear receptor Seven-up (SVP). SVP expression is confined to a temporally restricted subsection within the NB's lineage. Loss of SVP function causes an increase in the number of HB-positive cells within several NB lineages, whereas misexpression of svp leads to the loss of these early-born neurons. Lineage analysis provides evidence that svp is required to switch off HB at the proper time. Thus, svp modifies the self-renewal stem cell program to allow chronological change of cell fates, thereby generating neuronal diversity. |
巻・号 | 8(2) |
ページ | 203-13 |
公開日 | 2005-2-1 |
DOI | 10.1016/j.devcel.2004.12.014 |
PII | S1534-5807(04)00466-6 |
PMID | 15691762 |
MeSH | Animals Animals, Genetically Modified Cell Differentiation Cell Division Central Nervous System / cytology Central Nervous System / embryology DNA-Binding Proteins / genetics DNA-Binding Proteins / metabolism* Drosophila / cytology* Drosophila / genetics Drosophila / growth & development Drosophila / metabolism* Drosophila Proteins / genetics Drosophila Proteins / metabolism* Gene Expression Regulation, Developmental Genes, Insect Kruppel-Like Transcription Factors Multipotent Stem Cells / cytology Mutation Neurons / cytology* Receptors, Steroid / genetics Receptors, Steroid / metabolism* Repressor Proteins / genetics Repressor Proteins / metabolism Transcription Factors / genetics Transcription Factors / metabolism* |
IF | 10.092 |
引用数 | 102 |
WOS 分野 | DEVELOPMENTAL BIOLOGY CELL BIOLOGY |
リソース情報 | |
ショウジョウバエ |