RRC ID 353
著者 Kanai MI, Okabe M, Hiromi Y.
タイトル seven-up Controls switching of transcription factors that specify temporal identities of Drosophila neuroblasts.
ジャーナル Dev Cell
Abstract Drosophila neuronal stem cell neuroblasts (NB) constantly change character upon division, to produce a different type of progeny at the next division. Transcription factors Hunchback (HB), Krüppel (KR), Pdm (PDM), etc. are expressed sequentially in each NB and act as determinants of birth-order identity. How a NB switches its expression profile from one transcription factor to the next is poorly understood. We show that the HB-to-KR switch is directed by the nuclear receptor Seven-up (SVP). SVP expression is confined to a temporally restricted subsection within the NB's lineage. Loss of SVP function causes an increase in the number of HB-positive cells within several NB lineages, whereas misexpression of svp leads to the loss of these early-born neurons. Lineage analysis provides evidence that svp is required to switch off HB at the proper time. Thus, svp modifies the self-renewal stem cell program to allow chronological change of cell fates, thereby generating neuronal diversity.
巻・号 8(2)
ページ 203-13
公開日 2005-2-1
DOI 10.1016/j.devcel.2004.12.014
PII S1534-5807(04)00466-6
PMID 15691762
MeSH Animals Animals, Genetically Modified Cell Differentiation Cell Division Central Nervous System / cytology Central Nervous System / embryology DNA-Binding Proteins / genetics DNA-Binding Proteins / metabolism* Drosophila / cytology* Drosophila / genetics Drosophila / growth & development Drosophila / metabolism* Drosophila Proteins / genetics Drosophila Proteins / metabolism* Gene Expression Regulation, Developmental Genes, Insect Kruppel-Like Transcription Factors Multipotent Stem Cells / cytology Mutation Neurons / cytology* Receptors, Steroid / genetics Receptors, Steroid / metabolism* Repressor Proteins / genetics Repressor Proteins / metabolism Transcription Factors / genetics Transcription Factors / metabolism*
IF 10.092
引用数 102
WOS 分野 DEVELOPMENTAL BIOLOGY CELL BIOLOGY
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