RRC ID 3534
Author Phillips CM, Dernburg AF.
Title A family of zinc-finger proteins is required for chromosome-specific pairing and synapsis during meiosis in C. elegans.
Journal Dev. Cell
Abstract Homologous chromosome pairing and synapsis are prerequisite for accurate chromosome segregation during meiosis. Here, we show that a family of four related C2H2 zinc-finger proteins plays a central role in these events in C. elegans. These proteins are encoded within a tandem gene cluster. In addition to the X-specific HIM-8 protein, three additional paralogs collectively mediate the behavior of the five autosomes. Each chromosome relies on a specific member of the family to pair and synapse with its homolog. These "ZIM" proteins concentrate at special regions called meiotic pairing centers on the corresponding chromosomes. These sites are dispersed along the nuclear envelope during early meiotic prophase, suggesting a role analogous to the telomere-mediated meiotic bouquet in other organisms. To gain insight into the evolution of these components, we characterized homologs in C. briggsae and C. remanei, which revealed changes in copy number of this gene family within the nematode lineage.
Volume 11(6)
Pages 817-29
Published 2006-12
DOI 10.1016/j.devcel.2006.09.020
PII S1534-5807(06)00450-3
PMID 17141157
MeSH Amino Acid Sequence Animals Caenorhabditis elegans / genetics Caenorhabditis elegans / growth & development Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Cell Cycle Proteins / genetics Cell Cycle Proteins / metabolism Chromosomal Proteins, Non-Histone / genetics Chromosomal Proteins, Non-Histone / metabolism* Chromosome Pairing / physiology* Chromosome Segregation Chromosomes Evolution, Molecular In Situ Hybridization, Fluorescence Meiosis / physiology* Molecular Sequence Data Nuclear Envelope / metabolism Prophase Recombination, Genetic Sequence Homology, Amino Acid Telomere / physiology Zinc Fingers
IF 9.19
Times Cited 108
C.elegans tm756 tm574 tm2303 tm1813 tm1479