論文 - 詳細
| RRC ID | 3537 |
|---|---|
| 著者 | Prasad BC, Clark SG. |
| タイトル | Wnt signaling establishes anteroposterior neuronal polarity and requires retromer in C. elegans. |
| ジャーナル | Development |
| Abstract |
Secreted Wnt proteins influence neural connectivity by regulating axon guidance, dendritic morphogenesis and synapse formation. We report a new role for Wnt and Frizzled proteins in establishing the anteroposterior polarity of the mechanosensory neurons ALM and PLM in C. elegans. Disruption of Wnt signaling leads to a complete inversion of ALM and PLM polarity: the anterior process adopts the length, branching pattern and synaptic properties of the wild-type posterior process, and vice versa. Different but overlapping sets of Wnt proteins regulate neuronal polarity in different body regions. Wnts act directly on PLM via the Frizzled LIN-17. In addition, we show that they are needed for axon branching and anteriorly directed axon growth. We also find that the retromer, a conserved protein complex that mediates transcytosis and endosome-to-Golgi protein trafficking, plays a key role in Wnt signaling. Deletion mutations of retromer subunits cause ALM and PLM polarity, and other Wnt-related defects. We show that retromer protein VPS-35 is required in Wnt-expressing cells and propose that retromer activity is needed to generate a fully active Wnt signal. |
| 巻・号 | 133(9) |
| ページ | 1757-66 |
| 公開日 | 2006-5-1 |
| DOI | 10.1242/dev.02357 |
| PII | dev.02357 |
| PMID | 16571624 |
| MeSH | Animals Caenorhabditis elegans / cytology Caenorhabditis elegans / genetics Caenorhabditis elegans / growth & development Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / physiology* Cell Polarity* Green Fluorescent Proteins / metabolism Models, Biological Mutation Neurons, Afferent / cytology Neurons, Afferent / physiology RNA Interference Receptors, G-Protein-Coupled / genetics Receptors, G-Protein-Coupled / physiology* Signal Transduction* Vesicular Transport Proteins / genetics Wnt Proteins / genetics Wnt Proteins / physiology* |
| IF | 5.611 |
| 引用数 | 160 |
| WOS 分野 | DEVELOPMENTAL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | F1000Research |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm1320 tm1523 |