| RRC ID |
35558
|
| 著者 |
Méhi O, Bogos B, Csörgo B, Pál C.
|
| タイトル |
Genomewide screen for modulators of evolvability under toxic antibiotic exposure.
|
| ジャーナル |
Antimicrob Agents Chemother
|
| Abstract |
Antibiotic resistance is generally selected within a window of concentrations high enough to inhibit wild-type growth but low enough for new resistant mutants to emerge. We studied de novo evolution of resistance to ciprofloxacin in an Escherichia coli knockout library. Five null mutations had little or no effect on intrinsic antibiotic susceptibility but increased the upper antibiotic dosage to which initially sensitive populations could adapt. These mutations affect mismatch repair, translation fidelity, and iron homeostasis.
|
| 巻・号 |
57(7)
|
| ページ |
3453-6
|
| 公開日 |
2013-7-1
|
| DOI |
10.1128/AAC.02454-12
|
| PII |
AAC.02454-12
|
| PMID |
23669383
|
| PMC |
PMC3697378
|
| MeSH |
Adaptation, Biological
Anti-Bacterial Agents / pharmacology*
Ciprofloxacin / pharmacology*
Drug Resistance, Multiple, Bacterial / genetics*
Escherichia coli / drug effects*
Escherichia coli / genetics*
Evolution, Molecular*
Gene Library
Microbial Sensitivity Tests
Mutation
Selection, Genetic
|
| IF |
4.904
|
| 引用数 |
4
|
|
WOS 分野
|
PHARMACOLOGY & PHARMACY
MICROBIOLOGY
|
| リソース情報 |
| 原核生物(大腸菌) |
Keio collection |
