論文 - 詳細
| RRC ID | 3561 |
|---|---|
| 著者 | Audhya A, Desai A, Oegema K. |
| タイトル | A role for Rab5 in structuring the endoplasmic reticulum. |
| ジャーナル | J Cell Biol |
| Abstract |
The endoplasmic reticulum (ER) is a contiguous network of interconnected membrane sheets and tubules. The ER is differentiated into distinct domains, including the peripheral ER and nuclear envelope. Inhibition of two ER proteins, Rtn4a and DP1/NogoA, was previously shown to inhibit the formation of ER tubules in vitro. We show that the formation of ER tubules in vitro also requires a Rab family GTPase. Characterization of the 29 Caenorhabditis elegans Rab GTPases reveals that depletion of RAB-5 phenocopies the defects in peripheral ER structure that result from depletion of RET-1 and YOP-1, the C. elegans homologues of Rtn4a and DP1/NogoA. Perturbation of endocytosis by other means did not affect ER structure; the role of RAB-5 in ER morphology is thus independent of its well-studied requirement for endocytosis. RAB-5 and YOP-1/RET-1 also control the kinetics of nuclear envelope disassembly, which suggests an important role for the morphology of the peripheral ER in this process. |
| 巻・号 | 178(1) |
| ページ | 43-56 |
| 公開日 | 2007-7-2 |
| DOI | 10.1083/jcb.200701139 |
| PII | jcb.200701139 |
| PMID | 17591921 |
| PMC | PMC2064419 |
| MeSH | Animals Caenorhabditis elegans / genetics Caenorhabditis elegans / metabolism Cell Extracts / chemistry Embryo, Nonmammalian Endoplasmic Reticulum / metabolism* Female Green Fluorescent Proteins / metabolism Histones / genetics Histones / metabolism Models, Biological Ovum / chemistry RNA Interference RNA, Helminth Recombinant Fusion Proteins / metabolism Xenopus laevis rab5 GTP-Binding Proteins / metabolism* |
| IF | 8.811 |
| 引用数 | 80 |
| WOS 分野 | CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | F1000Research |
| 各媒体での言及数の合計 | 4 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm1512 |