Reference - Detail
| RRC ID | 35697 |
|---|---|
| Author | Yamagishi M, Nakano K, Miyake A, Yamochi T, Kagami Y, Tsutsumi A, Matsuda Y, Sato-Otsubo A, Muto S, Utsunomiya A, Yamaguchi K, Uchimaru K, Ogawa S, Watanabe T. |
| Title | Polycomb-mediated loss of miR-31 activates NIK-dependent NF-κB pathway in adult T cell leukemia and other cancers. |
| Journal | Cancer Cell |
| Abstract |
Constitutive NF-κB activation has causative roles in adult T cell leukemia (ATL) caused by HTLV-1 and other cancers. Here, we report a pathway involving Polycomb-mediated miRNA silencing and NF-κB activation. We determine the miRNA signatures and reveal miR-31 loss in primary ATL cells. MiR-31 negatively regulates the noncanonical NF-κB pathway by targeting NF-κB inducing kinase (NIK). Loss of miR-31 therefore triggers oncogenic signaling. In ATL cells, miR-31 level is epigenetically regulated, and aberrant upregulation of Polycomb proteins contribute to miR-31 downregulation in an epigenetic fashion, leading to activation of NF-κB and apoptosis resistance. Furthermore, this emerging circuit operates in other cancers and receptor-initiated NF-κB cascade. Our findings provide a perspective involving the epigenetic program, inflammatory responses, and oncogenic signaling. |
| Volume | 21(1) |
| Pages | 121-35 |
| Published | 2012-1-17 |
| DOI | 10.1016/j.ccr.2011.12.015 |
| PII | S1535-6108(11)00477-6 |
| PMID | 22264793 |
| MeSH | Epigenesis, Genetic Gene Expression Profiling Gene Expression Regulation, Neoplastic* Humans Leukemia-Lymphoma, Adult T-Cell / genetics* Leukemia-Lymphoma, Adult T-Cell / metabolism MicroRNAs / genetics* NF-kappa B / genetics NF-kappa B / metabolism* Oligonucleotide Array Sequence Analysis Polycomb-Group Proteins Protein Serine-Threonine Kinases / metabolism Protein Serine-Threonine Kinases / physiology* Repressor Proteins / genetics* Repressor Proteins / metabolism Repressor Proteins / physiology Signal Transduction T-Lymphocytes / metabolism T-Lymphocytes / pathology* |
| IF | 26.602 |
| Times Cited | 198 |
| WOS Category | ONCOLOGY CELL BIOLOGY |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | Patent(IFI CLAIMS) |
| Total number of mentions | 10 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| DNA material | CS-RfA-EVBsd (RDB06090) pENTR4-H1 (RDB04395) pCAG-HIVgp (RDB04394) pCMV-VSV-G-RSV-Rev (RDB04393). |