RRC ID 35698
Author Koyama-Nasu R, Haruta R, Nasu-Nishimura Y, Taniue K, Katou Y, Shirahige K, Todo T, Ino Y, Mukasa A, Saito N, Matsui M, Takahashi R, Hoshino-Okubo A, Sugano H, Manabe E, Funato K, Akiyama T.
Title The pleiotrophin-ALK axis is required for tumorigenicity of glioblastoma stem cells.
Journal Oncogene
Abstract Increasing evidence suggests that brain tumors arise from the transformation of neural stem/precursor/progenitor cells. Much current research on human brain tumors is focused on the stem-like properties of glioblastoma. Here we show that anaplastic lymphoma kinase (ALK) and its ligand pleiotrophin are required for the self-renewal and tumorigenicity of glioblastoma stem cells (GSCs). Furthermore, we demonstrate that pleiotrophin is transactivated directly by SOX2, a transcription factor essential for the maintenance of both neural stem cells and GSCs. We speculate that the pleiotrophin-ALK axis may be a promising target for the therapy of glioblastoma.
Volume 33(17)
Pages 2236-44
Published 2014-4-24
DOI 10.1038/onc.2013.168
PII onc2013168
PMID 23686309
MeSH Anaplastic Lymphoma Kinase Animals Brain Neoplasms / genetics Brain Neoplasms / metabolism* Brain Neoplasms / pathology Carcinogenesis / metabolism* Carrier Proteins / genetics* Carrier Proteins / metabolism Cell Proliferation Cytokines / genetics* Cytokines / metabolism Gene Expression Regulation, Neoplastic Glioblastoma / genetics Glioblastoma / metabolism* Glioblastoma / pathology HEK293 Cells Humans Mice Mice, Inbred BALB C Mice, Nude Neoplasm Transplantation Neoplastic Stem Cells / metabolism* Neoplastic Stem Cells / pathology Neoplastic Stem Cells / physiology Receptor Protein-Tyrosine Kinases / metabolism* SOXB1 Transcription Factors / metabolism Transcriptional Activation Tumor Cells, Cultured
IF 7.971
Times Cited 24
DNA material CS-RfA-CG (RDB04390) pCAG-HIVgp (RDB04394) pCMV-VSV-G-RSV-Rev (RDB04393).