Reference - Detail
| RRC ID | 3572 |
|---|---|
| Author | Fung WY, Fat KF, Eng CK, Lau CK. |
| Title | crm-1 facilitates BMP signaling to control body size in Caenorhabditis elegans. |
| Journal | Dev Biol |
| Abstract |
We have identified in Caenorhabditis elegans a homologue of the vertebrate Crim1, crm-1, which encodes a putative transmembrane protein with multiple cysteine-rich (CR) domains known to have bone morphogenetic proteins (BMPs) binding activity. Using the body morphology of C. elegans as an indicator, we showed that attenuation of crm-1 activity leads to a small body phenotype reminiscent of that of BMP pathway mutants. We showed that the crm-1 loss-of-function phenotype can be rescued by constitutive supply of sma-4 activity. crm-1 can enhance BMP signaling and this activity is dependent on the presence of the DBL-1 ligand and its receptors. crm-1 is expressed in neurons at the ventral nerve cord, where the DBL-1 ligand is produced. However, ectopic expression experiments reveal that crm-1 gene products act outside the DBL-1 producing cells and function non-autonomously to facilitate dbl/sma pathway signaling to control body size. |
| Volume | 311(1) |
| Pages | 95-105 |
| Published | 2007-11-1 |
| DOI | 10.1016/j.ydbio.2007.08.016 |
| PII | S0012-1606(07)01262-6 |
| PMID | 17869238 |
| MeSH | Animals Body Size* Bone Morphogenetic Proteins / metabolism* Caenorhabditis elegans / embryology* Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Gene Expression Regulation, Developmental Male Membrane Proteins / genetics Membrane Proteins / metabolism* Neuropeptides / metabolism Transforming Growth Factor beta / metabolism |
| IF | 2.896 |
| Times Cited | 15 |
| WOS Category | DEVELOPMENTAL BIOLOGY |
| Altmetric score |
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| Total number of mentions | 0 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| C.elegans | tm2218 |