論文 - 詳細
| RRC ID | 3585 |
|---|---|
| 著者 | Juo P, Harbaugh T, Garriga G, Kaplan JM. |
| タイトル | CDK-5 regulates the abundance of GLR-1 glutamate receptors in the ventral cord of Caenorhabditis elegans. |
| ジャーナル | Mol Biol Cell |
| Abstract |
The proline-directed kinase Cdk5 plays a role in several aspects of neuronal development. Here, we show that CDK-5 activity regulates the abundance of the glutamate receptor GLR-1 in the ventral cord of Caenorhabditis elegans and that it produces corresponding changes in GLR-1-dependent behaviors. Loss of CDK-5 activity results in decreased abundance of GLR-1 in the ventral cord, accompanied by accumulation of GLR-1 in neuronal cell bodies. Genetic analysis of cdk-5 and the clathrin adaptin unc-11 AP180 suggests that CDK-5 functions prior to endocytosis at the synapse. The scaffolding protein LIN-10/Mint-1 also regulates GLR-1 abundance in the nerve cord. CDK-5 phosphorylates LIN-10/Mint-1 in vitro and bidirectionally regulates the abundance of LIN-10/Mint-1 in the ventral cord. We propose that CDK-5 promotes the anterograde trafficking of GLR-1 and that phosphorylation of LIN-10 may play a role in this process. |
| 巻・号 | 18(10) |
| ページ | 3883-93 |
| 公開日 | 2007-10-1 |
| DOI | 10.1091/mbc.e06-09-0818 |
| PII | E06-09-0818 |
| PMID | 17671168 |
| PMC | PMC1995742 |
| MeSH | Animals Caenorhabditis elegans / enzymology* Caenorhabditis elegans Proteins / metabolism* Cyclin-Dependent Kinase 5 / chemistry Cyclin-Dependent Kinase 5 / metabolism* Down-Regulation / genetics Endocytosis Membrane Proteins / metabolism Mutation / genetics Nervous System / enzymology* Phosphorylation Protein Structure, Tertiary Protein Subunits / metabolism R-SNARE Proteins / metabolism Receptors, AMPA / metabolism* Recombinant Fusion Proteins / metabolism |
| IF | 3.791 |
| 引用数 | 21 |
| WOS 分野 | CELL BIOLOGY |
| リソース情報 | |
| 線虫 | tm648 |