論文 - 詳細
| RRC ID | 35986 |
|---|---|
| 著者 | Weber GF, Chousterman BG, He S, Fenn AM, Nairz M, Anzai A, Brenner T, Uhle F, Iwamoto Y, Robbins CS, Noiret L, Maier SL, Zönnchen T, Rahbari NN, Schölch S, Klotzsche-von Ameln A, Chavakis T, Weitz J, Hofer S, Weigand MA, Nahrendorf M, Weissleder R, Swirski FK. |
| タイトル | Interleukin-3 amplifies acute inflammation and is a potential therapeutic target in sepsis. |
| ジャーナル | Science |
| Abstract |
Sepsis is a frequently fatal condition characterized by an uncontrolled and harmful host reaction to microbial infection. Despite the prevalence and severity of sepsis, we lack a fundamental grasp of its pathophysiology. Here we report that the cytokine interleukin-3 (IL-3) potentiates inflammation in sepsis. Using a mouse model of abdominal sepsis, we showed that innate response activator B cells produce IL-3, which induces myelopoiesis of Ly-6C(high) monocytes and neutrophils and fuels a cytokine storm. IL-3 deficiency protects mice against sepsis. In humans with sepsis, high plasma IL-3 levels are associated with high mortality even after adjusting for prognostic indicators. This study deepens our understanding of immune activation, identifies IL-3 as an orchestrator of emergency myelopoiesis, and reveals a new therapeutic target for treating sepsis. |
| 巻・号 | 347(6227) |
| ページ | 1260-5 |
| 公開日 | 2015-3-13 |
| DOI | 10.1126/science.aaa4268 |
| PII | 347/6227/1260 |
| PMID | 25766237 |
| PMC | PMC4376966 |
| MeSH | Animals B-Lymphocyte Subsets / immunology Cytokines / immunology Cytokines / metabolism Disease Models, Animal Humans Inflammation Interleukin-3 / blood Interleukin-3 / immunology* Interleukin-3 / metabolism Lipopolysaccharides / immunology Lymphoid Tissue / immunology Mice Mice, Inbred BALB C Monocytes / immunology Myelopoiesis Neutrophils / immunology Peritonitis / immunology Peritonitis / pathology Prognosis Sepsis / immunology* Sepsis / mortality Sepsis / pathology Sepsis / therapy |
| IF | 41.846 |
| 引用数 | 125 |
| WOS 分野 | IMMUNOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | Google+ |
| 各媒体での言及数の合計 | 77 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 3.0 |
| リソース情報 | |
| 実験動物マウス | RBRC02298 |