論文 - 詳細
| RRC ID | 36040 |
|---|---|
| 著者 | Lv X, Pan C, Zhang Z, Xia Y, Chen H, Zhang S, Guo T, Han H, Song H, Zhang L, Zhao Y. |
| タイトル | SUMO regulates somatic cyst stem cell maintenance and directly targets the Hedgehog pathway in adult Drosophila testis. |
| ジャーナル | Development |
| Abstract |
SUMO (Small ubiquitin-related modifier) modification (SUMOylation) is a highly dynamic post-translational modification (PTM) that plays important roles in tissue development and disease progression. However, its function in adult stem cell maintenance is largely unknown. Here, we report the function of SUMOylation in somatic cyst stem cell (CySC) self-renewal in adult Drosophila testis. The SUMO pathway cell-autonomously regulates CySC maintenance. Reduction of SUMOylation promotes premature differentiation of CySCs and impedes the proliferation of CySCs, which leads to a reduction in the number of CySCs. Consistent with this, CySC clones carrying a mutation of the SUMO-conjugating enzyme are rapidly lost. Furthermore, inhibition of the SUMO pathway phenocopies disruption of the Hedgehog (Hh) pathway, and can block the proliferation of CySCs induced by Hh activation. Importantly, the SUMO pathway directly regulates the SUMOylation of Hh pathway transcription factor Cubitus interruptus (Ci), which is required for promoting CySC proliferation. Thus, we conclude that SUMO directly targets the Hh pathway and regulates CySC maintenance in adult Drosophila testis. |
| 巻・号 | 143(10) |
| ページ | 1655-62 |
| 公開日 | 2016-5-15 |
| DOI | 10.1242/dev.130773 |
| PII | dev.130773 |
| PMID | 27013244 |
| MeSH | Aging / physiology* Animals Cell Differentiation Cell Proliferation Drosophila Proteins / metabolism* Drosophila melanogaster / cytology Drosophila melanogaster / metabolism Epistasis, Genetic Hedgehog Proteins / metabolism* Male Signal Transduction* Small Ubiquitin-Related Modifier Proteins / metabolism* Stem Cells / cytology* Stem Cells / metabolism* Sumoylation Testis / cytology* Testis / metabolism |
| IF | 5.611 |
| 引用数 | 9 |
| WOS 分野 | DEVELOPMENTAL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 4 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | 2411R-1 |