論文 - 詳細
| RRC ID | 3609 |
|---|---|
| 著者 | Nakao F, Hudson ML, Suzuki M, Peckler Z, Kurokawa R, Liu Z, Gengyo-Ando K, Nukazuka A, Fujii T, Suto F, Shibata Y, Shioi G, Fujisawa H, Mitani S, Chisholm AD, Takagi S. |
| タイトル | The PLEXIN PLX-2 and the ephrin EFN-4 have distinct roles in MAB-20/Semaphorin 2A signaling in Caenorhabditis elegans morphogenesis. |
| ジャーナル | Genetics |
| Abstract |
Semaphorins are extracellular proteins that regulate axon guidance and morphogenesis by interacting with a variety of cell surface receptors. Most semaphorins interact with plexin-containing receptor complexes, although some interact with non-plexin receptors. Class 2 semaphorins are secreted molecules that control axon guidance and epidermal morphogenesis in Drosophila and Caenorhabditis elegans. We show that the C. elegans class 2 semaphorin MAB-20 binds the plexin PLX-2. plx-2 mutations enhance the phenotypes of hypomorphic mab-20 alleles but not those of mab-20 null alleles, indicating that plx-2 and mab-20 act in a common pathway. Both mab-20 and plx-2 mutations affect epidermal morphogenesis during embryonic and in postembryonic development. In both contexts, plx-2 null mutant phenotypes are much less severe than mab-20 null phenotypes, indicating that PLX-2 is not essential for MAB-20 signaling. Mutations in the ephrin efn-4 do not synergize with mab-20, indicating that EFN-4 may act in MAB-20 signaling. EFN-4 and PLX-2 are coexpressed in the late embryonic epidermis where they play redundant roles in MAB-20-dependent cell sorting. |
| 巻・号 | 176(3) |
| ページ | 1591-607 |
| 公開日 | 2007-7-1 |
| DOI | 10.1534/genetics.106.067116 |
| PII | genetics.106.067116 |
| PMID | 17507686 |
| PMC | PMC1931547 |
| MeSH | Animals Caenorhabditis elegans / physiology Caenorhabditis elegans Proteins / metabolism* Caenorhabditis elegans Proteins / physiology Cell Adhesion Molecules / physiology* Ephrin-A4 / physiology* Membrane Proteins / metabolism* Morphogenesis* Nerve Tissue Proteins / metabolism* Nerve Tissue Proteins / physiology* Semaphorins / metabolism* Signal Transduction |
| IF | 4.015 |
| 引用数 | 20 |
| WOS 分野 | GENETICS & HEREDITY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| 線虫 | tm729 |