論文 - 詳細
| RRC ID | 36101 |
|---|---|
| 著者 | Gadaleta MC, González-Medina A, Noguchi E. |
| タイトル | Timeless protection of telomeres. |
| ジャーナル | Curr Genet |
| Abstract |
The DNA replication machinery encounters problems at numerous genomic regions that are inherently difficult to replicate. These genomic regions include telomeres, which contain repetitive DNA and telomere-binding proteins. If not properly regulated, replication of such genomic regions can result in DNA damage, leading to genomic instability. Studies implicated a role of Timeless-related proteins at difficult-to-replicate genomic regions, including telomeres. However, how these proteins maintain telomeres was elusive. In a recent report, we described the role of Swi1, a Timeless-related protein, in telomere maintenance in fission yeast. We demonstrated that Swi1 is required for proper replication of repeat DNA sequences at telomeres. We also showed that Swi1-deficient cells utilize recombination-based ALT (alternative lengthening of telomeres)-like mechanisms to maintain telomeres in the absence of telomerase. Here, we highlight these findings and present additional data to discuss the role of Swi1Timeless in telomere protection and ALT prevention. |
| 巻・号 | 62(4) |
| ページ | 725-730 |
| 公開日 | 2016-11-1 |
| DOI | 10.1007/s00294-016-0599-x |
| PII | 10.1007/s00294-016-0599-x |
| PMID | 27068713 |
| PMC | PMC5056121 |
| MeSH | Carrier Proteins Chromosomal Proteins, Non-Histone / metabolism DNA Damage DNA Replication DNA-Directed DNA Polymerase / metabolism Genome Genomics Protein Binding Recombinases / antagonists & inhibitors Recombinases / metabolism Recombination, Genetic Repetitive Sequences, Nucleic Acid Telomerase / metabolism Telomere / genetics* Telomere / metabolism* Telomere Homeostasis |
| IF | 3.464 |
| 引用数 | 15 |
| WOS 分野 | GENETICS & HEREDITY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 酵母 | S. pombe strains ? |