| RRC ID |
36236
|
| 著者 |
Ge W, Deng Q, Guo T, Hong X, Kugler JM, Yang X, Cohen SM.
|
| タイトル |
Regulation of pattern formation and gene amplification during Drosophila oogenesis by the miR-318 microRNA.
|
| ジャーナル |
Genetics
|
| Abstract |
Pattern formation during epithelial development requires the coordination of multiple signaling pathways. Here, we investigate the functions of an ovary-enriched miRNA, miR-318, in epithelial development during Drosophila oogenesis. mir-318 maternal loss-of-function mutants were female-sterile and laid eggs with abnormal morphology. Removal of mir-318 disrupted the dorsal-anterior follicle cell patterning, resulting in abnormal dorsal appendages. mir-318 mutant females also produced thin and fragile eggshells due to impaired chorion gene amplification. We provide evidence that the ecdysone signaling pathway activates expression of miR-318 and that miR-318 cooperates with Tramtrack69 to control the switch from endocycling to chorion gene amplification during differentiation of the follicular epithelium. The multiple functions of miR-318 in oogenesis illustrate the importance of miRNAs in maintaining cell fate and in promoting the developmental transition in the female follicular epithelium.
|
| 巻・号 |
200(1)
|
| ページ |
255-65
|
| 公開日 |
2015-5-1
|
| DOI |
10.1534/genetics.115.174748
|
| PII |
genetics.115.174748
|
| PMID |
25786856
|
| PMC |
PMC4423367
|
| MeSH |
Animals
Body Patterning*
Drosophila Proteins / genetics
Drosophila Proteins / metabolism
Drosophila melanogaster / embryology
Drosophila melanogaster / genetics*
Drosophila melanogaster / metabolism
Female
Gene Amplification*
Gene Expression Regulation, Developmental
MicroRNAs / genetics*
Mutation
Oogenesis*
Repressor Proteins / genetics
Repressor Proteins / metabolism
Signal Transduction
|
| IF |
4.015
|
| 引用数 |
10
|
|
WOS 分野
|
GENETICS & HEREDITY
|
| リソース情報 |
| ショウジョウバエ |
DGRC#206424 |
