論文 - 詳細
| RRC ID | 36236 |
|---|---|
| 著者 | Ge W, Deng Q, Guo T, Hong X, Kugler JM, Yang X, Cohen SM. |
| タイトル | Regulation of pattern formation and gene amplification during Drosophila oogenesis by the miR-318 microRNA. |
| ジャーナル | Genetics |
| Abstract |
Pattern formation during epithelial development requires the coordination of multiple signaling pathways. Here, we investigate the functions of an ovary-enriched miRNA, miR-318, in epithelial development during Drosophila oogenesis. mir-318 maternal loss-of-function mutants were female-sterile and laid eggs with abnormal morphology. Removal of mir-318 disrupted the dorsal-anterior follicle cell patterning, resulting in abnormal dorsal appendages. mir-318 mutant females also produced thin and fragile eggshells due to impaired chorion gene amplification. We provide evidence that the ecdysone signaling pathway activates expression of miR-318 and that miR-318 cooperates with Tramtrack69 to control the switch from endocycling to chorion gene amplification during differentiation of the follicular epithelium. The multiple functions of miR-318 in oogenesis illustrate the importance of miRNAs in maintaining cell fate and in promoting the developmental transition in the female follicular epithelium. |
| 巻・号 | 200(1) |
| ページ | 255-65 |
| 公開日 | 2015-5-1 |
| DOI | 10.1534/genetics.115.174748 |
| PII | genetics.115.174748 |
| PMID | 25786856 |
| PMC | PMC4423367 |
| MeSH | Animals Body Patterning* Drosophila Proteins / genetics Drosophila Proteins / metabolism Drosophila melanogaster / embryology Drosophila melanogaster / genetics* Drosophila melanogaster / metabolism Female Gene Amplification* Gene Expression Regulation, Developmental MicroRNAs / genetics* Mutation Oogenesis* Repressor Proteins / genetics Repressor Proteins / metabolism Signal Transduction |
| IF | 4.015 |
| 引用数 | 10 |
| WOS 分野 | GENETICS & HEREDITY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 6 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | DGRC#206424 |