RRC ID 3626
Author Rimann I, Hajnal A.
Title Regulation of anchor cell invasion and uterine cell fates by the egl-43 Evi-1 proto-oncogene in Caenorhabditis elegans.
Journal Dev. Biol.
Abstract Cell invasion is a tightly controlled process occurring during development and tumor progression. The nematode Caenorhabditis elegans serves as a genetic model to study cell invasion during normal development. In the third larval stage, the anchor cell in the somatic gonad first induces and then invades the adjacent epidermal vulval precursor cells. The homolog of the Evi-1 oncogene, egl-43, is necessary for basement membrane destruction and anchor cell invasion. egl-43 is part of a regulatory network mediating cell invasion downstream of the fos-1 proto-oncogene. In addition, EGL-43 is required to specify the cell fates of ventral uterus cells downstream of or in parallel with LIN-12 NOTCH. Comparison with mammalian Evi-1 suggests a conserved pathway controlling cell invasion and cell fate specification.
Volume 308(1)
Pages 187-95
Published 2007-8-1
DOI 10.1016/j.ydbio.2007.05.023
PII S0012-1606(07)01047-0
PMID 17573066
MeSH Animals Animals, Genetically Modified Cadherins / genetics Cadherins / metabolism Caenorhabditis elegans / cytology Caenorhabditis elegans / genetics* Caenorhabditis elegans / growth & development* Caenorhabditis elegans / metabolism Caenorhabditis elegans Proteins / genetics* Caenorhabditis elegans Proteins / metabolism Female Gene Expression Regulation, Developmental Genes, Helminth Models, Biological Proto-Oncogene Proteins c-fos / genetics Proto-Oncogene Proteins c-fos / metabolism Proto-Oncogenes RNA Interference Transcription Factors / genetics* Transcription Factors / metabolism Uterus / cytology Uterus / growth & development Uterus / metabolism
IF 2.936
Times Cited 22
C.elegans tm1802