RRC ID 36288
Author Lin AC, Bygrave AM, de Calignon A, Lee T, Miesenböck G.
Title Sparse, decorrelated odor coding in the mushroom body enhances learned odor discrimination.
Journal Nat Neurosci
Abstract Sparse coding may be a general strategy of neural systems for augmenting memory capacity. In Drosophila melanogaster, sparse odor coding by the Kenyon cells of the mushroom body is thought to generate a large number of precisely addressable locations for the storage of odor-specific memories. However, it remains untested how sparse coding relates to behavioral performance. Here we demonstrate that sparseness is controlled by a negative feedback circuit between Kenyon cells and the GABAergic anterior paired lateral (APL) neuron. Systematic activation and blockade of each leg of this feedback circuit showed that Kenyon cells activated APL and APL inhibited Kenyon cells. Disrupting the Kenyon cell-APL feedback loop decreased the sparseness of Kenyon cell odor responses, increased inter-odor correlations and prevented flies from learning to discriminate similar, but not dissimilar, odors. These results suggest that feedback inhibition suppresses Kenyon cell activity to maintain sparse, decorrelated odor coding and thus the odor specificity of memories.
Volume 17(4)
Pages 559-68
Published 2014-4-1
DOI 10.1038/nn.3660
PII nn.3660
PMID 24561998
PMC PMC4000970
MeSH Animals Animals, Genetically Modified Behavior, Animal / physiology Discrimination, Psychological / physiology Drosophila Proteins / genetics Drosophila melanogaster / physiology Feedback, Physiological / physiology GABAergic Neurons / cytology GABAergic Neurons / metabolism GABAergic Neurons / physiology Learning / physiology* Mushroom Bodies / cytology Mushroom Bodies / physiology* Neural Inhibition / physiology Odorants Olfactory Perception / physiology* Up-Regulation / physiology*
IF 20.071
Times Cited 101
Drosophila DGRC#104266