論文 - 詳細
| RRC ID | 36307 |
|---|---|
| 著者 | Ray RP, Matamoro-Vidal A, Ribeiro PS, Tapon N, Houle D, Salazar-Ciudad I, Thompson BJ. |
| タイトル | Patterned Anchorage to the Apical Extracellular Matrix Defines Tissue Shape in the Developing Appendages of Drosophila. |
| ジャーナル | Dev Cell |
| Abstract |
How tissues acquire their characteristic shape is a fundamental unresolved question in biology. While genes have been characterized that control local mechanical forces to elongate epithelial tissues, genes controlling global forces in epithelia have yet to be identified. Here, we describe a genetic pathway that shapes appendages in Drosophila by defining the pattern of global tensile forces in the tissue. In the appendages, shape arises from tension generated by cell constriction and localized anchorage of the epithelium to the cuticle via the apical extracellular-matrix protein Dumpy (Dp). Altering Dp expression in the developing wing results in predictable changes in wing shape that can be simulated by a computational model that incorporates only tissue contraction and localized anchorage. Three other wing shape genes, narrow, tapered, and lanceolate, encode components of a pathway that modulates Dp distribution in the wing to refine the global force pattern and thus wing shape. |
| 巻・号 | 34(3) |
| ページ | 310-22 |
| 公開日 | 2015-8-10 |
| DOI | 10.1016/j.devcel.2015.06.019 |
| PII | S1534-5807(15)00426-8 |
| PMID | 26190146 |
| PMC | PMC4539345 |
| MeSH | Animals Body Patterning* Cell Adhesion Drosophila Proteins / genetics Drosophila Proteins / metabolism* Drosophila melanogaster / embryology* Epithelium / metabolism* Extracellular Matrix / metabolism Extracellular Matrix Proteins / genetics Extracellular Matrix Proteins / metabolism* Gene Expression Regulation, Developmental Ion Channels / metabolism Protein Structure, Tertiary RNA Interference RNA, Small Interfering Signal Transduction / genetics Wings, Animal / embryology* |
| IF | 10.092 |
| 引用数 | 43 |
| WOS 分野 | DEVELOPMENTAL BIOLOGY CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 11 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | DGRC#115238 |