RRC ID 36354
Author Hamamoto H, Sekimizu K.
Title Identification of lysocin E using a silkworm model of bacterial infection.
Journal Drug Discov Ther
Abstract New antimicrobials with novel mechanisms need to be developed to combat antimicrobial-resistant pathogenic bacteria. The current authors recently reported discovery of a new antibiotic named "Lysocin E". Lysocin E was identified using a silkworm model of bacterial infection. The current review discusses the advantages of using a silkworm model of bacterial infection to identify and develop therapeutically efficacious antimicrobials. This review also discusses the discovery of lysocin E and its novel mechanism of action.
Volume 10(1)
Pages 24-9
Published 2016-2-1
DOI 10.5582/ddt.2016.01012
PMID 26911796
MeSH Animals Anti-Bacterial Agents / pharmacology* Bacterial Infections / drug therapy* Bacterial Infections / microbiology Bombyx / drug effects* Bombyx / embryology Bombyx / microbiology Disease Models, Animal Drug Discovery / methods* Drug Resistance, Multiple, Bacterial Humans Larva / drug effects Larva / microbiology Molecular Structure Peptides, Cyclic / pharmacology* Species Specificity
Times Cited 1
Resource
Silkworms