RRC ID 36538
著者 Van Driessche N, Shaw C, Katoh M, Morio T, Sucgang R, Ibarra M, Kuwayama H, Saito T, Urushihara H, Maeda M, Takeuchi I, Ochiai H, Eaton W, Tollett J, Halter J, Kuspa A, Tanaka Y, Shaulsky G.
タイトル A transcriptional profile of multicellular development in Dictyostelium discoideum.
ジャーナル Development
Abstract A distinct feature of development in the simple eukaryote Dictyostelium discoideum is an aggregative transition from a unicellular to a multicellular phase. Using genome-wide transcriptional analysis we show that this transition is accompanied by a dramatic change in the expression of more than 25% of the genes in the genome. We also show that the transcription patterns of these genes are not sensitive to the strain or the nutritional history, indicating that Dictyostelium development is a robust physiological process that is accompanied by stereotypical transcriptional events. Analysis of the two differentiated cell types, spores and stalk cells, and their precursors revealed a large number of differentially expressed genes as well as unexpected patterns of gene expression, which shed new light on the timing and possible mechanisms of cell-type divergence. Our findings provide new perspectives on the complexity of the developmental program and the fraction of the genome that is regulated during development.
巻・号 129(7)
ページ 1543-52
公開日 2002-4-1
DOI 10.1242/dev.129.7.1543
PMID 11923193
MeSH Animals Dictyostelium / cytology Dictyostelium / genetics* Dictyostelium / growth & development* Gene Expression Profiling Gene Expression Regulation, Developmental Genome, Protozoan Oligonucleotide Array Sequence Analysis Reproducibility of Results Transcription, Genetic
IF 5.611
引用数 103
WOS 分野 DEVELOPMENTAL BIOLOGY
リソース情報
細胞性粘菌