RRC ID 36667
Author Tang H, Mori Y.
Title Determinants of Human CD134 Essential for Entry of Human Herpesvirus 6B.
Journal J Virol
Abstract We identified two key amino acid residues within human CD134 (hCD134) that are required for its interaction with human herpesvirus 6B (HHV-6B) and for HHV-6B entry into cells. One of the residues (K79) allows access of the HHV-6B ligand to hCD134. Murine CD134 (mCD134) functioned as an HHV-6B receptor when these two amino acid residues were replaced with homologous human residues. This study identifies both the HHV-6B receptor-ligand interaction and the species-specific determinants of hCD134 essential for HHV-6B entry.
Volume 89(19)
Pages 10125-9
Published 2015-10-1
DOI 10.1128/JVI.01606-15
PII JVI.01606-15
PMID 26202244
PMC PMC4577881
MeSH Amino Acid Sequence Amino Acid Substitution Animals Cell Line Crystallography, X-Ray Herpesvirus 6, Human / pathogenicity Herpesvirus 6, Human / physiology* Host-Pathogen Interactions / genetics Host-Pathogen Interactions / physiology Humans Ligands Mice Models, Molecular Molecular Sequence Data Mutagenesis, Site-Directed Protein Conformation Receptors, OX40 / chemistry* Receptors, OX40 / genetics Receptors, OX40 / physiology* Receptors, Virus / chemistry Receptors, Virus / genetics Receptors, Virus / physiology Sequence Homology, Amino Acid Virus Internalization*
IF 4.501
Times Cited 8
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