論文 - 詳細
| RRC ID | 36667 |
|---|---|
| 著者 | Tang H, Mori Y. |
| タイトル | Determinants of Human CD134 Essential for Entry of Human Herpesvirus 6B. |
| ジャーナル | J Virol |
| Abstract |
We identified two key amino acid residues within human CD134 (hCD134) that are required for its interaction with human herpesvirus 6B (HHV-6B) and for HHV-6B entry into cells. One of the residues (K79) allows access of the HHV-6B ligand to hCD134. Murine CD134 (mCD134) functioned as an HHV-6B receptor when these two amino acid residues were replaced with homologous human residues. This study identifies both the HHV-6B receptor-ligand interaction and the species-specific determinants of hCD134 essential for HHV-6B entry. |
| 巻・号 | 89(19) |
| ページ | 10125-9 |
| 公開日 | 2015-10-1 |
| DOI | 10.1128/JVI.01606-15 |
| PII | JVI.01606-15 |
| PMID | 26202244 |
| PMC | PMC4577881 |
| MeSH | Amino Acid Sequence Amino Acid Substitution Animals Cell Line Crystallography, X-Ray Herpesvirus 6, Human / pathogenicity Herpesvirus 6, Human / physiology* Host-Pathogen Interactions / genetics Host-Pathogen Interactions / physiology Humans Ligands Mice Models, Molecular Molecular Sequence Data Mutagenesis, Site-Directed Protein Conformation Receptors, OX40 / chemistry* Receptors, OX40 / genetics Receptors, OX40 / physiology* Receptors, Virus / chemistry Receptors, Virus / genetics Receptors, Virus / physiology Sequence Homology, Amino Acid Virus Internalization* |
| IF | 4.501 |
| 引用数 | 8 |
| WOS 分野 | VIROLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| 研究用ヒト臍帯血幹細胞 | 研究用ヒト臍帯血幹細胞 |