RRC ID 36667
Author Tang H, Mori Y.
Title Determinants of Human CD134 Essential for Entry of Human Herpesvirus 6B.
Journal J. Virol.
Abstract We identified two key amino acid residues within human CD134 (hCD134) that are required for its interaction with human herpesvirus 6B (HHV-6B) and for HHV-6B entry into cells. One of the residues (K79) allows access of the HHV-6B ligand to hCD134. Murine CD134 (mCD134) functioned as an HHV-6B receptor when these two amino acid residues were replaced with homologous human residues. This study identifies both the HHV-6B receptor-ligand interaction and the species-specific determinants of hCD134 essential for HHV-6B entry.
Volume 89(19)
Pages 10125-9
Published 2015-10
DOI 10.1128/JVI.01606-15
PII JVI.01606-15
PMID 26202244
PMC PMC4577881
MeSH Amino Acid Sequence Amino Acid Substitution Animals Cell Line Crystallography, X-Ray Herpesvirus 6, Human / pathogenicity Herpesvirus 6, Human / physiology* Host-Pathogen Interactions / genetics Host-Pathogen Interactions / physiology Humans Ligands Mice Models, Molecular Molecular Sequence Data Mutagenesis, Site-Directed Protein Conformation Receptors, OX40 / chemistry* Receptors, OX40 / genetics Receptors, OX40 / physiology* Receptors, Virus / chemistry Receptors, Virus / genetics Receptors, Virus / physiology Sequence Homology, Amino Acid Virus Internalization*
IF 4.324
Times Cited 0
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