論文 - 詳細
| RRC ID | 36736 |
|---|---|
| 著者 | Takeshita T, Arita T, Asao H, Tanaka N, Higuchi M, Kuroda H, Kaneko K, Munakata H, Endo Y, Fujita T, Sugamura K. |
| タイトル | Cloning of a novel signal-transducing adaptor molecule containing an SH3 domain and ITAM. |
| ジャーナル | Biochem Biophys Res Commun |
| Abstract |
We molecularly cloned a cDNA coding for a novel phosphotyrosine molecule with a 70 kDa molecular mass, named STAM (signal transducing adaptor molecule), which is tyrosine-phosphorylated rapidly after stimulation with various cytokines such as IL-2, IL-3, IL-4, IL-7, GM-CSF, EGF and PDGF. STAM contains an SH3 (Src-homology 3) domain and the ITAM (immunoreceptor tyrosine-based activation motif), suggesting that STAM acts as an adaptor molecule involved in signal transducing pathways from the cytokine receptors. |
| 巻・号 | 225(3) |
| ページ | 1035-9 |
| 公開日 | 1996-8-23 |
| DOI | 10.1006/bbrc.1996.1290 |
| PII | S0006-291X(96)91290-5 |
| PMID | 8780729 |
| MeSH | Adaptor Proteins, Signal Transducing* Amino Acid Sequence Animals Cell Line Chromosome Mapping Cloning, Molecular Cytokines / pharmacology DNA, Complementary / genetics Endosomal Sorting Complexes Required for Transport Humans Mice Molecular Sequence Data Molecular Weight Phosphoproteins / chemistry Phosphoproteins / genetics* Phosphoproteins / metabolism Phosphorylation Proteins / chemistry Proteins / genetics* Proteins / metabolism Receptors, Cytokine / metabolism Sequence Homology, Amino Acid Signal Transduction* Tyrosine / metabolism src Homology Domains |
| IF | 2.985 |
| 引用数 | 66 |
| WOS 分野 | BIOPHYSICS BIOCHEMISTRY & MOLECULAR BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 8 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 遺伝子材料 | pBluescript-STAM-1 (RDB01792) |