Reference - Detail
| RRC ID | 36923 |
|---|---|
| Author | Ono A, Ito A, Suzuki T, Yamaguchi M, Kawabe Y, Kamihira M. |
| Title | DNA damage-responsive transgene expression mediated by the p53 promoter with transcriptional amplification. |
| Journal | J Biosci Bioeng |
| Abstract |
We constructed a DNA damage-responsive transgene expression system mediated by the p53 promoter. We incorporated a transactivation system to generate transcriptional amplification via a positive feedback loop. Higher levels of DNA damage-responsive transgene expression were observed when transactivation was active. |
| Volume | 120(4) |
| Pages | 463-6 |
| Published | 2015-10-1 |
| DOI | 10.1016/j.jbiosc.2015.02.009 |
| PII | S1389-1723(15)00087-0 |
| PMID | 25772439 |
| MeSH | 3T3 Cells Animals DNA Damage / drug effects DNA Damage / genetics* Feedback, Physiological / drug effects Humans Mice Mutagenicity Tests* Promoter Regions, Genetic / genetics* Tetracycline / pharmacology Transcription, Genetic / drug effects Transcription, Genetic / genetics* Transcriptional Activation / drug effects Transcriptional Activation / genetics* Transgenes / genetics* Tumor Suppressor Protein p53 / genetics* Up-Regulation / drug effects Up-Regulation / genetics |
| IF | 2.366 |
| Times Cited | 1 |
| WOS Category | BIOTECHNOLOGY & APPLIED MICROBIOLOGY FOOD SCIENCE & TECHNOLOGY |
| Resource | |
| Human and Animal Cells | 293(RCB1637) |