RRC ID 37015
Author Feng X, Scott A, Wang Y, Wang L, Zhao Y, Doerner S, Satake M, Croniger CM, Wang Z.
Title PTPRT regulates high-fat diet-induced obesity and insulin resistance.
Journal PLoS One
Abstract Obesity is a risk factor for many human diseases. However, the underlying molecular causes of obesity are not well understood. Here, we report that protein tyrosine phosphatase receptor T (PTPRT) knockout mice are resistant to high-fat diet-induced obesity. Those mice avoid many deleterious side effects of high-fat diet-induced obesity, displaying improved peripheral insulin sensitivity, lower blood glucose and insulin levels. Compared to wild type littermates, PTPRT knockout mice show reduced food intake. Consistently, STAT3 phosphorylation is up-regulated in the hypothalamus of PTPRT knockout mice. These studies implicate PTPRT-modulated STAT3 signaling in the regulation of high-fat diet-induced obesity.
Volume 9(6)
Pages e100783
Published 2014-1-1
DOI 10.1371/journal.pone.0100783
PII PONE-D-14-05187
PMID 24949727
PMC PMC4065109
MeSH Animals Blood Glucose Diet, High-Fat Dietary Fats Humans Hypothalamus / metabolism Insulin / blood Insulin Resistance / genetics* Mice Mice, Knockout Obesity / blood Obesity / genetics* Obesity / pathology Receptor-Like Protein Tyrosine Phosphatases, Class 2 / genetics* STAT3 Transcription Factor / biosynthesis* STAT3 Transcription Factor / metabolism Signal Transduction / genetics
IF 2.74
Times Cited 6
Mice RBRC01489