論文 - 詳細
| RRC ID | 37015 |
|---|---|
| 著者 | Feng X, Scott A, Wang Y, Wang L, Zhao Y, Doerner S, Satake M, Croniger CM, Wang Z. |
| タイトル | PTPRT regulates high-fat diet-induced obesity and insulin resistance. |
| ジャーナル | PLoS One |
| Abstract |
Obesity is a risk factor for many human diseases. However, the underlying molecular causes of obesity are not well understood. Here, we report that protein tyrosine phosphatase receptor T (PTPRT) knockout mice are resistant to high-fat diet-induced obesity. Those mice avoid many deleterious side effects of high-fat diet-induced obesity, displaying improved peripheral insulin sensitivity, lower blood glucose and insulin levels. Compared to wild type littermates, PTPRT knockout mice show reduced food intake. Consistently, STAT3 phosphorylation is up-regulated in the hypothalamus of PTPRT knockout mice. These studies implicate PTPRT-modulated STAT3 signaling in the regulation of high-fat diet-induced obesity. |
| 巻・号 | 9(6) |
| ページ | e100783 |
| 公開日 | 2014-1-1 |
| DOI | 10.1371/journal.pone.0100783 |
| PII | PONE-D-14-05187 |
| PMID | 24949727 |
| PMC | PMC4065109 |
| MeSH | Animals Blood Glucose Diet, High-Fat Dietary Fats Humans Hypothalamus / metabolism Insulin / blood Insulin Resistance / genetics* Mice Mice, Knockout Obesity / blood Obesity / genetics* Obesity / pathology Receptor-Like Protein Tyrosine Phosphatases, Class 2 / genetics* STAT3 Transcription Factor / biosynthesis* STAT3 Transcription Factor / metabolism Signal Transduction / genetics |
| IF | 2.74 |
| 引用数 | 6 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 実験動物マウス | RBRC01489 |