| RRC ID |
37015
|
| 著者 |
Feng X, Scott A, Wang Y, Wang L, Zhao Y, Doerner S, Satake M, Croniger CM, Wang Z.
|
| タイトル |
PTPRT regulates high-fat diet-induced obesity and insulin resistance.
|
| ジャーナル |
PLoS One
|
| Abstract |
Obesity is a risk factor for many human diseases. However, the underlying molecular causes of obesity are not well understood. Here, we report that protein tyrosine phosphatase receptor T (PTPRT) knockout mice are resistant to high-fat diet-induced obesity. Those mice avoid many deleterious side effects of high-fat diet-induced obesity, displaying improved peripheral insulin sensitivity, lower blood glucose and insulin levels. Compared to wild type littermates, PTPRT knockout mice show reduced food intake. Consistently, STAT3 phosphorylation is up-regulated in the hypothalamus of PTPRT knockout mice. These studies implicate PTPRT-modulated STAT3 signaling in the regulation of high-fat diet-induced obesity.
|
| 巻・号 |
9(6)
|
| ページ |
e100783
|
| 公開日 |
2014-1-1
|
| DOI |
10.1371/journal.pone.0100783
|
| PII |
PONE-D-14-05187
|
| PMID |
24949727
|
| PMC |
PMC4065109
|
| MeSH |
Animals
Blood Glucose
Diet, High-Fat
Dietary Fats
Humans
Hypothalamus / metabolism
Insulin / blood
Insulin Resistance / genetics*
Mice
Mice, Knockout
Obesity / blood
Obesity / genetics*
Obesity / pathology
Receptor-Like Protein Tyrosine Phosphatases, Class 2 / genetics*
STAT3 Transcription Factor / biosynthesis*
STAT3 Transcription Factor / metabolism
Signal Transduction / genetics
|
| IF |
2.74
|
| 引用数 |
6
|
|
WOS 分野
|
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
| リソース情報 |
| 実験動物マウス |
RBRC01489 |
