論文 - 詳細
| RRC ID | 37035 |
|---|---|
| 著者 | Kwon J, Park M, Kim JH, Lee HW, Kang MC, Park JH. |
| タイトル | Epigenetic regulation of the novel tumor suppressor cysteine dioxygenase 1 in esophageal squamous cell carcinoma. |
| ジャーナル | Tumour Biol |
| Abstract |
Esophageal squamous cell carcinoma (ESCC), the most common subtype of esophageal cancer in East Asian countries, is still associated with a poor prognosis because of the high frequency of lymph node metastasis and invasion. In our previous study, we identified a novel methylation gene, cysteine dioxygenase 1 (CDO1) that is involved in the conversion of cysteine to cysteine sulfinate, and plays a key role in taurine biosynthesis. Decreased expression of CDO1 was observed in ESCC cell lines and tumors derived from patient tissues, and CDO1 silencing could be reversed by treatment with 5-aza-2'-deoxycytidine in six ESCC cell lines. Forced expression of CDO1 in three different ESCC cell lines, TE-4, TE-6, and TE-14, significantly decreased tumor cell growth, cell migration, invasion, and the ability of colony formation. Although CDO1 expression was not found to significantly correlate with survival in ESCC patients, our results suggest that methylation-regulated CDO1 may represent a functional tumor suppressor and a potentially valuable diagnostic biomarker for ESCC. |
| 巻・号 | 36(10) |
| ページ | 7449-56 |
| 公開日 | 2015-9-1 |
| DOI | 10.1007/s13277-015-3443-x |
| PII | 10.1007/s13277-015-3443-x |
| PMID | 25903467 |
| MeSH | Aged Apoptosis Blotting, Western Carcinoma, Squamous Cell / genetics* Carcinoma, Squamous Cell / mortality Carcinoma, Squamous Cell / pathology Case-Control Studies Cell Movement Cell Proliferation Cysteine Dioxygenase / genetics* DNA Methylation* Epigenesis, Genetic / genetics* Esophageal Neoplasms / genetics* Esophageal Neoplasms / mortality Esophageal Neoplasms / pathology Female Follow-Up Studies Gene Expression Regulation, Neoplastic* Gene Silencing Humans Immunoenzyme Techniques Male Neoplasm Grading Neoplasm Invasiveness Neoplasm Recurrence, Local / genetics* Neoplasm Recurrence, Local / mortality Neoplasm Recurrence, Local / pathology Neoplasm Staging Prognosis Promoter Regions, Genetic / genetics RNA, Messenger / genetics Real-Time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction Survival Rate Tumor Cells, Cultured |
| IF | 3.65 |
| 引用数 | 10 |
| WOS 分野 | ONCOLOGY |
| リソース情報 | |
| ヒト・動物細胞 | TE-1(RCB1894) TE-4(RCB2097) TE-5(RCB1949) TE-6(RCB1950) TE-8(RCB2098) TE-9(RCB1988) TE-10(RCB2099) TE-11(RCB2100) TE-14(RCB2101) TE-15(RCB1951) |