論文 - 詳細
| RRC ID | 37499 |
|---|---|
| 著者 | Mizowaki T, Sasayama T, Tanaka K, Mizukawa K, Takata K, Nakamizo S, Tanaka H, Nagashima H, Nishihara M, Hirose T, Itoh T, Kohmura E. |
| タイトル | STAT3 activation is associated with cerebrospinal fluid interleukin-10 (IL-10) in primary central nervous system diffuse large B cell lymphoma. |
| ジャーナル | J Neurooncol |
| Abstract |
Signal transducers and activators of transcription 3 (STAT3) are activated by various cytokines and oncogenes; however, the activity and pathogenesis of STAT3 in diffuse large B cell lymphoma of the central nervous system have not been thoroughly elucidated. We investigated the phosphorylation levels of STAT3 in 40 specimens of primary central nervous system diffuse large B-cell lymphoma (PCNS DLBCL) and analyzed the association between phsopho-STAT3 (pSTAT3) expression and cerebrospinal fluid (CSF) concentration of interleukin-10 (IL-10) or IL-6. Immunohistochemistry and Western blot analysis revealed that most of the specimens in PCNS DLBCL expressed pSTST3 protein, and a strong phosphorylation levels of STAT3 was statistically associated with high CSF IL-10 levels, but not with CSF IL-6 levels. Next, we demonstrated that recombinant IL-10 and CSF containing IL-10 induced the phosphorylation of STAT3 in PCNS DLBCL cells. Furthermore, molecular subtype classified by Hans' algorithm was correlated with pSTAT3 expression levels and CSF IL-10 levels. These results suggest that the STAT3 activity is correlated with CSF IL-10 level, which is a useful marker for STAT3 activity in PCNS DLBCLs. |
| 巻・号 | 124(2) |
| ページ | 165-74 |
| 公開日 | 2015-9-1 |
| DOI | 10.1007/s11060-015-1843-9 |
| PII | 10.1007/s11060-015-1843-9 |
| PMID | 26080800 |
| MeSH | Adult Aged Aged, 80 and over Animals Biomarkers / metabolism Cell Line, Tumor Central Nervous System Neoplasms / classification Central Nervous System Neoplasms / diagnosis Central Nervous System Neoplasms / metabolism* Central Nervous System Neoplasms / pathology Female Humans Interleukin-10 / metabolism* Interleukin-6 / metabolism Lymphoma, Large B-Cell, Diffuse / classification Lymphoma, Large B-Cell, Diffuse / diagnosis Lymphoma, Large B-Cell, Diffuse / metabolism* Lymphoma, Large B-Cell, Diffuse / pathology Male Mice, Inbred BALB C Mice, Nude Middle Aged Neoplasm Transplantation Phosphorylation Prognosis Recombinant Proteins / metabolism STAT3 Transcription Factor / metabolism* |
| IF | 3.267 |
| 引用数 | 7 |
| WOS 分野 | CLINICAL NEUROLOGY ONCOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| ヒト・動物細胞 | HKBML(RCB0820) |