| RRC ID |
37519
|
| 著者 |
Jin H, Zhang Y, You H, Tao X, Wang C, Jin G, Wang N, Ruan H, Gu D, Huo X, Cong W, Qin W.
|
| タイトル |
Prognostic significance of kynurenine 3-monooxygenase and effects on proliferation, migration, and invasion of human hepatocellular carcinoma.
|
| ジャーナル |
Sci Rep
|
| Abstract |
Kynurenine 3-monooxygenase (KMO) is a pivotal enzyme in the kynurenine pathway of tryptophan degradation and plays a critical role in Huntington's and Alzheimer's diseases. This study aimed to examine the expression of KMO in human hepatocellular carcinoma (HCC) and investigate the relationship between its expression and prognosis of HCC patients. We first analyzed KMO expression in 120 paired HCC samples (HCC tissues vs matched adjacent non-cancerous liver tissues), and 205 clinical HCC specimens using immunohistochemistry (IHC). Kaplan-Meier survival and Cox regression analyses were executed to evaluate the prognosis of HCC. The results of IHC analysis showed that KMO expression was significantly higher in HCC tissues than that in normal liver tissues (all p < 0.05). Survival and recurrence analyses showed that KMO was an independent prognostic factor for overall survival (OS) and time to recurrence (TTR) (both p<0.01). And in vitro studies revealed that KMO positively regulated proliferation, migration, and invasion of HCC cells. These results suggest that KMO exhibits tumor-promoting effects towards HCC and it may serve as a novel prognostic marker in HCC.
|
| 巻・号 |
5
|
| ページ |
10466
|
| 公開日 |
2015-6-23
|
| DOI |
10.1038/srep10466
|
| PII |
srep10466
|
| PMID |
26099564
|
| PMC |
PMC4479133
|
| MeSH |
Aged
Carcinoma, Hepatocellular / enzymology*
Carcinoma, Hepatocellular / pathology*
Cell Line, Tumor
Cell Movement*
Cell Proliferation
Female
Gene Knockdown Techniques
Humans
Kynurenine 3-Monooxygenase / metabolism*
Liver Neoplasms / enzymology*
Liver Neoplasms / pathology*
Male
Middle Aged
Multivariate Analysis
Neoplasm Invasiveness
Neoplasm Recurrence, Local / enzymology
Neoplasm Recurrence, Local / pathology
Prognosis
Proportional Hazards Models
RNA, Small Interfering / metabolism
Up-Regulation
|
| IF |
3.998
|
| 引用数 |
27
|
|
WOS 分野
|
ONCOLOGY
|
| リソース情報 |
| ヒト・動物細胞 |
HuH-7(RCB1366) |
