論文 - 詳細
| RRC ID | 37651 |
|---|---|
| 著者 | Ishikawa H, Takeda K, Okamoto A, Matsuo S, Isobe K. |
| タイトル | Induction of autoimmunity in a bleomycin-induced murine model of experimental systemic sclerosis: an important role for CD4+ T cells. |
| ジャーナル | J Invest Dermatol |
| Abstract |
Systemic sclerosis (SSc) is an autoimmune disease characterized by the excessive deposition of collagen in the skin or other organs and the production of specific antinuclear antibodies (ANAs). Recently, bleomycin (BLM)-induced experimental scleroderma was reported in a murine model. Here, we present further development of this model and suggest that it is appropriate for the analysis of human diffuse type SSc. BLM was injected into the shaved backs of C3H or BALB/c mice (100 microg/mouse) 5 days per week for 3 weeks. Skin fibrosis was confirmed and pathological changes were seen in the lower part of the esophagus and stomach similar to those seen in SSc. The sera from these mice had autoantibodies specific to the damaged tissues and ANAs. Transfer of CD4(+) T cells from BLM-treated BALB/c mice induced the same pathological changes and antibody production in untreated-BALB/c nude mice. Hence, tissue fibrosis and the production of ANAs are probably associated with CD4(+) T-cell activity in this model. In conclusion, this model will be valuable for investigating the relationship between tissue fibrosis and abnormalities of the immune system. |
| 巻・号 | 129(7) |
| ページ | 1688-95 |
| 公開日 | 2009-7-1 |
| DOI | 10.1038/jid.2008.431 |
| PII | S0022-202X(15)34405-5 |
| PMID | 19158840 |
| MeSH | Adoptive Transfer Animals Antibiotics, Antineoplastic / toxicity Antibodies, Antineutrophil Cytoplasmic / immunology Autoimmunity / immunology* Bleomycin / toxicity CD4-Positive T-Lymphocytes / immunology* CD4-Positive T-Lymphocytes / transplantation Disease Models, Animal Female Fibrosis Mice Mice, Inbred BALB C Mice, Inbred C3H Mice, Nude Scleroderma, Systemic / chemically induced Scleroderma, Systemic / immunology* Scleroderma, Systemic / pathology* Skin / immunology Skin / pathology |
| IF | 7.143 |
| 引用数 | 40 |
| WOS 分野 | DERMATOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | NIH3T3 |