Reference - Detail
| RRC ID | 37733 |
|---|---|
| Author | Ikezoe T, Takeuchi T, Yang J, Adachi Y, Nishioka C, Furihata M, Koeffler HP, Yokoyama A. |
| Title | Analysis of Aurora B kinase in non-Hodgkin lymphoma. |
| Journal | Lab Invest |
| Abstract |
This study explored the levels of Aurora B, a key regulator of mitosis, in 71 lymph nodes and tumor specimens excised operatively from individuals with various types of non-Hodgkin lymphoma (NHLs). Immunohistochemical examination found that diffuse large B-cell lymphoma (10/21, 48%) and Burkitt lymphoma (BL) (6/7, 86%) cells highly (percentage of positive cells, >20%) expressed Aurora B in their nuclei. On the other hand, none of the low-grade B-cell lymphoma (n=20), except for one case of follicular lymphoma, highly expressed this protein kinase, suggesting that levels of Aurora B correlated with histological grade in B-cell NHLs (P<0.01). Exposure of BL/leukemia cells to AZD1152-HQPA in vitro, a selective inhibitor of Aurora B kinase, potently induced growth arrest and apoptosis in a caspase-dependent, as well as -independent manner. Moreover, AZD1152 synergistically enhanced the effects of vincristine (VCR) to induce growth arrest of these cells. Further experiments found that VCR increased levels of the p-Aurora B through the activation of c-Jun N-terminal kinase, which was blocked in the presence of AZD1152-HQPA. |
| Volume | 89(12) |
| Pages | 1364-73 |
| Published | 2009-12-1 |
| DOI | 10.1038/labinvest.2009.106 |
| PII | labinvest2009106 |
| PMID | 19823168 |
| MeSH | Adult Aged Aged, 80 and over Apoptosis / drug effects Aurora Kinase B Aurora Kinases Caspases / metabolism Cell Line, Tumor Cell Proliferation / drug effects Drug Synergism Enzyme Activation Humans JNK Mitogen-Activated Protein Kinases / metabolism Lymphoma, Non-Hodgkin / enzymology* Middle Aged Organophosphates / pharmacology Phosphorylation Protein Serine-Threonine Kinases / antagonists & inhibitors Protein Serine-Threonine Kinases / metabolism* Quinazolines / pharmacology Signal Transduction / drug effects Tubulin Modulators / pharmacology Vincristine / pharmacology Young Adult |
| IF | 4.197 |
| Times Cited | 30 |
| WOS Category | PATHOLOGY MEDICINE, RESEARCH & EXPERIMENTAL |
| Altmetric score |
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| Total number of mentions | 0 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | DAUDI(RCB1640) |