論文 - 詳細
| RRC ID | 37756 |
|---|---|
| 著者 | Mizuno Y, Tokuzawa Y, Ninomiya Y, Yagi K, Yatsuka-Kanesaki Y, Suda T, Fukuda T, Katagiri T, Kondoh Y, Amemiya T, Tashiro H, Okazaki Y. |
| タイトル | miR-210 promotes osteoblastic differentiation through inhibition of AcvR1b. |
| ジャーナル | FEBS Lett |
| Abstract |
Although microRNAs (miRNAs) are involved in many biological processes, the mechanisms whereby miRNAs regulate osteoblastic differentiation are poorly understood. Here, we found that BMP-4-induced osteoblastic differentiation of bone marrow-derived ST2 stromal cells was promoted and repressed after transfection of sense and antisense miR-210, respectively. A reporter assay demonstrated that the activin A receptor type 1B (AcvR1b) gene was a target for miR-210. Furthermore, inhibition of transforming growth factor-beta (TGF-beta)/activin signaling in ST2 cells with SB431542 promoted osteoblastic differentiation. We conclude that miR-210 acts as a positive regulator of osteoblastic differentiation by inhibiting the TGF-beta/activin signaling pathway through inhibition of AcvR1b. |
| 巻・号 | 583(13) |
| ページ | 2263-8 |
| 公開日 | 2009-7-7 |
| DOI | 10.1016/j.febslet.2009.06.006 |
| PII | S0014-5793(09)00449-9 |
| PMID | 19520079 |
| MeSH | Activin Receptors, Type I / antagonists & inhibitors* Activin Receptors, Type I / metabolism Animals Bone Morphogenetic Protein 4 / metabolism Cell Differentiation* Cells, Cultured Mice MicroRNAs / metabolism* Osteoblasts / cytology* Osteoblasts / metabolism Signal Transduction Transfection Transforming Growth Factor beta / metabolism |
| IF | 3.057 |
| 引用数 | 169 |
| WOS 分野 | BIOPHYSICS BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 4 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | ST2(RCB0224) NRG(RCB1921) |