| RRC ID |
37812
|
| Author |
Wang X, Lam EK, Zhang J, Jin H, Sung JJ.
|
| Title |
MicroRNA-122a functions as a novel tumor suppressor downstream of adenomatous polyposis coli in gastrointestinal cancers.
|
| Journal |
Biochem Biophys Res Commun
|
| Abstract |
Aberrant regulation of APC/beta-catenin signaling pathway is common in the pathogenesis of colorectal and other cancers. Targets regulated by APC/beta-catenin signaling pathway play crucial roles in cancer development. In the current study, we aimed to illustrate the influence of APC/beta-catenin signaling pathway on expression of microRNAs, one new group of players important to carcinogenesis. Restoration of APC function in colorectal cancer cells led to the deregulation of several cancer-related microRNAs, such as miR-122a which was recognized as the liver-specific microRNA. MiR-122a was down-regulated in gastrointestinal cancer cell lines as well as primary carcinoma tissues. Inhibition of miR-122a could reverse wild-type APC-induced growth inhibition of gastrointestinal cancer cells while miR-122a mimic inhibited cell growth. In summary, we identified some cancer-related microRNAs regulated by APC/beta-catenin signaling pathway. The down-regulation of miR-122a mediated by aberrant APC/beta-catenin signaling is important to the pathogenesis of gastrointestinal cancers.
|
| Volume |
387(2)
|
| Pages |
376-80
|
| Published |
2009-9-18
|
| DOI |
10.1016/j.bbrc.2009.07.034
|
| PII |
S0006-291X(09)01380-1
|
| PMID |
19607815
|
| MeSH |
Adenomatous Polyposis Coli / genetics*
Carcinoma / genetics*
Cell Line, Tumor
Down-Regulation
Gene Expression Profiling
Gene Expression Regulation, Neoplastic*
Genes, Tumor Suppressor*
Humans
MicroRNAs / genetics*
beta Catenin / metabolism*
|
| IF |
2.985
|
| Times Cited |
28
|
|
WOS Category
|
BIOPHYSICS
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
| Resource |
| Human and Animal Cells |
|
