論文 - 詳細
| RRC ID | 38219 |
|---|---|
| 著者 | Kawamichi Y, Cui CH, Toyoda M, Makino H, Horie A, Takahashi Y, Matsumoto K, Saito H, Ohta H, Saito K, Umezawa A. |
| タイトル | Cells of extraembryonic mesodermal origin confer human dystrophin in the mdx model of Duchenne muscular dystrophy. |
| ジャーナル | J Cell Physiol |
| Abstract |
Duchenne muscular dystrophy is an X-linked recessive genetic disease characterized by severe skeletal muscular degeneration. The placenta is considered to be a promising candidate cell source for cellular therapeutics because it contains a large number of cells and heterogenous cell populations with myogenic potentials. We analyzed the myogenic potential of cells obtained from six parts of the placenta, that is, umbilical cord, amniotic epithelium, amniotic mesoderm, chorionic plate, villous chorion, and decidua basalis. In vitro cells derived from amniotic mesoderm, chorionic plate, and villous chorion efficiently transdifferentiate into myotubes. In addition, in vivo implantation of placenta-derived cells into dystrophic muscles of immunodeficient mdx mice restored sarcolemmal expression of human dystrophin. Differential contribution to myogenesis in this study may be attributed to placental portion-dependent default cell state. Molecular taxonomic characterization of placenta-derived maternal and fetal cells in vitro will help determine the feasibility of cell-based therapy. |
| 巻・号 | 223(3) |
| ページ | 695-702 |
| 公開日 | 2010-6-1 |
| DOI | 10.1002/jcp.22076 |
| PMID | 20162617 |
| MeSH | Animals Biomarkers / metabolism Cell Membrane / metabolism Cell Shape Cell Transplantation Disease Models, Animal Dystrophin / metabolism* Extraembryonic Membranes / cytology* Extraembryonic Membranes / transplantation* Female Humans Mesoderm / cytology* Mesoderm / transplantation* Mice Mice, Inbred mdx Mice, SCID Muscle Development Muscle Fibers, Skeletal / metabolism Muscle Fibers, Skeletal / pathology Muscular Dystrophy, Duchenne / metabolism Muscular Dystrophy, Duchenne / pathology Muscular Dystrophy, Duchenne / therapy* Oligonucleotide Array Sequence Analysis Placenta / cytology Pregnancy |
| IF | 5.546 |
| 引用数 | 19 |
| WOS 分野 | PHYSIOLOGY CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | |