論文 - 詳細
| RRC ID | 38294 |
|---|---|
| 著者 | Arung ET, Shimizu K, Tanaka H, Kondo R. |
| タイトル | 3-Prenyl luteolin, a new prenylated flavone with melanin biosynthesis inhibitory activity from wood of Artocarpus heterophyllus. |
| ジャーナル | Fitoterapia |
| Abstract |
In our efforts to find new whitening agent from natural resources, we focused on wood of Artocarpus heterophyllus which shows anti-melanogenesis activity. By activity-guided fractionation of A. heterophyllus wood extract, a new prenylated flavonoid, 3-prenyl luteolin (1) was isolated. The IC(50) of mushroom tyrosinase inhibitory activity of 1 was 76.3 microM. The results of the comparison with that of luteolin showed the prenyl substituent at C-3 position of 1 play an important role for revealing tyrosinase inhibition. In melanin formation inhibition on B16 melanoma cells, IC(50) of 1 was 56.7 microM with less cytotoxicity. |
| 巻・号 | 81(6) |
| ページ | 640-3 |
| 公開日 | 2010-9-1 |
| DOI | 10.1016/j.fitote.2010.03.011 |
| PII | S0367-326X(10)00070-5 |
| PMID | 20230878 |
| MeSH | Animals Artocarpus / chemistry* Cell Line, Tumor Drug Evaluation, Preclinical Flavones / chemistry Flavones / isolation & purification Flavones / pharmacology* Luteolin / chemistry Luteolin / isolation & purification* Melanins / antagonists & inhibitors* Melanins / biosynthesis Mice Monophenol Monooxygenase / antagonists & inhibitors* Plants, Medicinal / chemistry Wood / chemistry |
| IF | 2.527 |
| 引用数 | 21 |
| WOS 分野 | PHARMACOLOGY & PHARMACY CHEMISTRY, MEDICINAL |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | B16 |