RRC ID 38294
著者 Arung ET, Shimizu K, Tanaka H, Kondo R.
タイトル 3-Prenyl luteolin, a new prenylated flavone with melanin biosynthesis inhibitory activity from wood of Artocarpus heterophyllus.
ジャーナル Fitoterapia
Abstract In our efforts to find new whitening agent from natural resources, we focused on wood of Artocarpus heterophyllus which shows anti-melanogenesis activity. By activity-guided fractionation of A. heterophyllus wood extract, a new prenylated flavonoid, 3-prenyl luteolin (1) was isolated. The IC(50) of mushroom tyrosinase inhibitory activity of 1 was 76.3 microM. The results of the comparison with that of luteolin showed the prenyl substituent at C-3 position of 1 play an important role for revealing tyrosinase inhibition. In melanin formation inhibition on B16 melanoma cells, IC(50) of 1 was 56.7 microM with less cytotoxicity.
巻・号 81(6)
ページ 640-3
公開日 2010-9-1
DOI 10.1016/j.fitote.2010.03.011
PII S0367-326X(10)00070-5
PMID 20230878
MeSH Animals Artocarpus / chemistry* Cell Line, Tumor Drug Evaluation, Preclinical Flavones / chemistry Flavones / isolation & purification Flavones / pharmacology* Luteolin / chemistry Luteolin / isolation & purification* Melanins / antagonists & inhibitors* Melanins / biosynthesis Mice Monophenol Monooxygenase / antagonists & inhibitors* Plants, Medicinal / chemistry Wood / chemistry
IF 2.527
引用数 21
WOS 分野 PHARMACOLOGY & PHARMACY CHEMISTRY, MEDICINAL
リソース情報
ヒト・動物細胞